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B1VG49 (DDL_CORU7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:cu0778
OrganismCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]
Taxonomic identifier504474 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000091177

Regions

Domain153 – 357205ATP-grasp
Nucleotide binding180 – 23556ATP By similarity

Sites

Metal binding3121Magnesium or manganese 1 By similarity
Metal binding3241Magnesium or manganese 1 By similarity
Metal binding3241Magnesium or manganese 2 By similarity
Metal binding3261Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B1VG49 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 7DCA9BC16CBE8DBD

FASTA36238,130
        10         20         30         40         50         60 
MTAAEKLTVA VVYGGQSTEH SVSCISAGAI IDNLDPERFT VVPVGITNGG AWVPGATDTA 

        70         80         90        100        110        120 
QLRASGRELP TVADHGEHIQ PMLGAAGEAT EFRFVTGDRA GDVFATADVI FPVLHGANGE 

       130        140        150        160        170        180 
DGTIQGLFDL LGARYVGNGV LASAAGMDKE FTKKIAREAG IPTGPEVVLH GRTELTDHER 

       190        200        210        220        230        240 
ELLGLPVFVK PARGGSSIGI SKVDSWRDLP AAIEEAASHD PKVIIEAMIT GPEVECGVLE 

       250        260        270        280        290        300 
REDGTLVASS PAMLEGTDAG EEGFYGFDAK YLDDTVSATI PAPLDEETTR RVQQLAIETY 

       310        320        330        340        350        360 
RALGCTGLAR VDFFVTDAGP VLNEINTMPG FTPISMYPQM FLADGVSYAD LLTTLVSGAR 


RH 

« Hide

References

[1]"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
J. Biotechnol. 136:11-21(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM942444 Genomic DNA. Translation: CAQ04738.1.
RefSeqYP_001800172.1. NC_010545.1.

3D structure databases

ProteinModelPortalB1VG49.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING504474.cur_0778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ04738; CAQ04738; cu0778.
GeneID6184893.
KEGGcur:cur_0778.
PATRIC21521282. VBICorUre58120_0777.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycCURE504474:GJ8Y-794-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_CORU7
AccessionPrimary (citable) accession number: B1VG49
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways