B1VEK0 (B1VEK0_CORU7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

cu0229

Organism

Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]

Taxonomic identifier

504474 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase RuleBase RU000515 EMBL CAQ04189.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	224	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	276	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	261	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	234	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	245	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	302	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	341	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	B1VEK0 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 4C0341DC7ED13C22	FASTA	352	37,987
	10 20 30 40 50 60 MVSAPWRTIG VMSESAQNSQ LQFNIPRRPR RLRTNPVMRD FTAETSLNPS QLVLPMFVAD 70 80 90 100 110 120 GLTDAKPISS LPGVYQHTTD SLLRAVEEAA EAGVGSIDLF GVPLDEDKDA TGSVGVDPEG 130 140 150 160 170 180 ILNKNLRAIR KEFGNDILVM ADTCLDEFTD HGHCGVQGED AFGHQIVDND ATLEQYAALA 190 200 210 220 230 240 VAQADAGAHI VSPSGMMDGQ VAVIRAALDA SGHEDVSIMA YSAKYASAFY GPFREAVGSS 250 260 270 280 290 300 LTGDRRTYQQ DPRNRRESLL ETQMDIDEGA DMVMVKPAMP YLDVLREVAD MSPVPVAAYQ 310 320 330 340 350 VSGEYAMISA AAQNGWIDLE PAIMESLTGI RRAGADIILT YWATTAAKML RG

References

[1]

"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing." Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A. J. Biotechnol. 136:11-21(2008) [PubMed: 18367281] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM942444 Genomic DNA. Translation: CAQ04189.1.
RefSeq	YP_001799623.1. NC_010545.1.
3D structure databases
ProteinModelPortal	B1VEK0.
ModBase	Search...
Protein-protein interaction databases
STRING	B1VEK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6185164.
GenomeReviews	Gene locus cu0229 in contig AM942444_GR.
KEGG	cur:cur_0229.
PATRIC	21520156. VBICorUre58120_0225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	FTSHGHD.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1VEK0_CORU7

Accession

Primary (citable) accession number: B1VEK0

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)