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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 911D-inositol 3-phosphateUniRule annotation
Binding sitei23 – 231UDP-GlcNAc; via amide nitrogenUniRule annotation
Binding sitei78 – 7811D-inositol 3-phosphateUniRule annotation
Binding sitei110 – 11011D-inositol 3-phosphateUniRule annotation
Binding sitei134 – 13411D-inositol 3-phosphateUniRule annotation
Binding sitei154 – 15411D-inositol 3-phosphateUniRule annotation
Binding sitei231 – 2311UDP-GlcNAcUniRule annotation
Binding sitei236 – 2361UDP-GlcNAcUniRule annotation
Binding sitei295 – 2951UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation
Metal bindingi304 – 3041Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi305 – 3051Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi307 – 3071Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei317 – 3171UDP-GlcNAcUniRule annotation
Binding sitei325 – 3251UDP-GlcNAcUniRule annotation
Metal bindingi331 – 3311MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCURE504474:GJ8Y-219-MONOMER.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:cu0213
OrganismiCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Taxonomic identifieri504474 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001727 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424D-inositol 3-phosphate glycosyltransferasePRO_0000400121Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi504474.cur_0213.

Structurei

3D structure databases

ProteinModelPortaliB1VEI4.
SMRiB1VEI4. Positions 1-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 2561D-inositol 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13579. Glyco_trans_4_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

B1VEI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAMISMHT SPLEQAGTGD AGGMNVYIRN TAEQLAKLGL SVDIFTRATR
60 70 80 90 100
PLQGEVVELG DGVRVINCVA GPYEGLSKEE LPTQLAAFTG SVLAFTRQHG
110 120 130 140 150
LSYDLIHSHY WLSGQVAWLL RDLWNIRWVH TPHTLAAVKN NYLSEGDHRE
160 170 180 190 200
PESRRICEQQ IVDNADVLIV NTDAEVADVE EGYDSHKARI AVVTPGADIE
210 220 230 240 250
KFTPGTERAT ENARRALGIP LSAKVIGFVG RLQRLKGPHV LLQAAATLIE
260 270 280 290 300
RYPDMPIRVL ICGGPSGSGL ERPKCLEELA EELGISRAVR FLKPRPPEEL
310 320 330 340 350
VSIYQAADVV AMPSANESFG LVALEAQATG TPVVATRIGG LQAAVAEGKS
360 370 380 390 400
GLLVDGQDPQ AWADALGQLL SDDDQRIAMA EYAPQHAARY SWENTAKQLV
410 420
ELYRSLPTMP EEGPAERHPA GSAN
Length:424
Mass (Da):45,970
Last modified:May 20, 2008 - v1
Checksum:i72D92D1F18D6788F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942444 Genomic DNA. Translation: CAQ04173.1.
RefSeqiWP_012359479.1. NC_010545.1.

Genome annotation databases

EnsemblBacteriaiCAQ04173; CAQ04173; cu0213.
KEGGicur:cu0213.
PATRICi21520124. VBICorUre58120_0209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942444 Genomic DNA. Translation: CAQ04173.1.
RefSeqiWP_012359479.1. NC_010545.1.

3D structure databases

ProteinModelPortaliB1VEI4.
SMRiB1VEI4. Positions 1-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi504474.cur_0213.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ04173; CAQ04173; cu0213.
KEGGicur:cu0213.
PATRICi21520124. VBICorUre58120_0209.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Enzyme and pathway databases

BioCyciCURE504474:GJ8Y-219-MONOMER.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13579. Glyco_trans_4_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_CORU7
AccessioniPrimary (citable) accession number: B1VEI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.