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B1VEE1

- TRMB_CORU7

UniProt

B1VEE1 - TRMB_CORU7

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, cu0170
Organism
Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021S-adenosyl-L-methionine By similarity
Binding sitei127 – 1271S-adenosyl-L-methionine By similarity
Binding sitei154 – 1541S-adenosyl-L-methionine By similarity
Active sitei177 – 1771 By similarity
Binding sitei177 – 1771S-adenosyl-L-methionine By similarity
Binding sitei181 – 1811Substrate By similarity
Binding sitei213 – 2131Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCURE504474:GJ8Y-176-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:cu0170
    OrganismiCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
    Taxonomic identifieri504474 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000001727: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_1000149654Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi504474.cur_0170.

    Structurei

    3D structure databases

    ProteinModelPortaliB1VEE1.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni261 – 2644Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiLHIATDH.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1VEE1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSNNSPQD DHQQALSEEN SAPATEVTGG TGRRPLQTVF NDGRDYPRLS    50
    SFAFRRGTLT DNQEATWEAN WPRLGKELDE QVNEQYIDLD EWFGRHADTI 100
    VEIGSGTGTS TAAMAPLETD KNIVAVELYR PGLAKLVGAV SREGIENIRM 150
    IKGDGVEVLQ RMFRPESLAG VRIFFPDPWP KARHHKRRIV QTGTLHLIAS 200
    RLRPGGILHI ATDHAEYAEW IDELVNAEPQ LEYIGWPEEL ASGADDGRGH 250
    LGQLVDRQLL TKFEDKGLRK EHTIKEYLWT KK 282
    Length:282
    Mass (Da):31,749
    Last modified:May 20, 2008 - v1
    Checksum:i999421B764F4F223
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942444 Genomic DNA. Translation: CAQ04130.1.
    RefSeqiWP_012359436.1. NC_010545.1.
    YP_001799564.1. NC_010545.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ04130; CAQ04130; cu0170.
    GeneIDi6186263.
    KEGGicur:cur_0170.
    PATRICi21520042. VBICorUre58120_0168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942444 Genomic DNA. Translation: CAQ04130.1 .
    RefSeqi WP_012359436.1. NC_010545.1.
    YP_001799564.1. NC_010545.1.

    3D structure databases

    ProteinModelPortali B1VEE1.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 504474.cur_0170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ04130 ; CAQ04130 ; cu0170 .
    GeneIDi 6186263.
    KEGGi cur:cur_0170.
    PATRICi 21520042. VBICorUre58120_0168.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi LHIATDH.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CURE504474:GJ8Y-176-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
      Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
      J. Biotechnol. 136:11-21(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43042 / DSM 7109.

    Entry informationi

    Entry nameiTRMB_CORU7
    AccessioniPrimary (citable) accession number: B1VEE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 20, 2008
    Last modified: September 3, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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