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B1VDH7 (B1VDH7_CORU7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP MF_00218
Short name=UPD HAMAP MF_00218
Short name=URO-D HAMAP MF_00218
EC=4.1.1.37 HAMAP MF_00218
Gene names
Name:hemE HAMAP MF_00218
Ordered Locus Names:cu0915
OrganismCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109) [Complete proteome] [HAMAP]
Taxonomic identifier504474 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 RuleBase RU000554 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen III from 5-aminolevulinate: step 4/4. RuleBase RU000554

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP MF_00218 RuleBase RU004169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region46 – 505Substrate binding By similarity HAMAP MF_00218

Sites

Binding site951Substrate By similarity HAMAP MF_00218
Binding site1711Substrate By similarity HAMAP MF_00218
Binding site2261Substrate By similarity HAMAP MF_00218
Binding site3521Substrate By similarity HAMAP MF_00218
Site951Transition state stabilizer By similarity HAMAP MF_00218

Sequences

Sequence LengthMass (Da)Tools
B1VDH7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: DC5A604EF0ADE212

FASTA37340,756
        10         20         30         40         50         60 
MGAMTNELLT PDLAAASAAR RADADAPYLA AVRGDKPSRR PVWMMRQAGR SLPEYRKVRE 

        70         80         90        100        110        120 
GIPMLDSCFM PDLLAEITMQ PVIRHDADAA ILFSDIVVPL KAAGMDVEIV AGRGPVMGEA 

       130        140        150        160        170        180 
VRTSEQIANI PDLEPDQLGP IVEGIEQILE RLRTDQVLIG FAGAPFTVAS YLIEGGPSKN 

       190        200        210        220        230        240 
HEVTKAMMYA EPQLWHALME KLSPMIAHFL QAQIEAGVDA IQLFDSWAGF LTARDYREYV 

       250        260        270        280        290        300 
APYSQKILDA VRPYGIPMTH FGVGTGELLV DLAKVGPDVV GVDWRVPMNV AAKRVQQALP 

       310        320        330        340        350        360 
DQTPKAYQGN LDPAVLFAGR DVIREHVKRI AAEAYEAIEL GYSRGHIFNL GHGVMPHTDA 

       370 
DAITAAFEEV HNS

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References

[1]"The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
J. Biotechnol. 136:11-21(2008) [PubMed: 18367281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43042 / DSM 7109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM942444 Genomic DNA. Translation: CAQ04875.1.
RefSeqYP_001800309.1. NC_010545.1.

3D structure databases

ProteinModelPortalB1VDH7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1VDH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6185211.
GenomeReviewsGene locus cu0915 in contig AM942444_GR.
KEGGcur:cur_0915.
PATRIC21521558. VBICorUre58120_0915.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO_D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1VDH7_CORU7
AccessionPrimary (citable) accession number: B1VDH7
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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