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B1VDC1

- PNP_CORU7

UniProt

B1VDC1 - PNP_CORU7

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, cu0859
Organism
Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi556 – 5561Magnesium By similarity
Metal bindingi562 – 5621Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCURE504474:GJ8Y-875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:cu0859
OrganismiCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Taxonomic identifieri504474 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001727: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000381880Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi504474.cur_0859.

Structurei

3D structure databases

ProteinModelPortaliB1VDC1.
SMRiB1VDC1. Positions 34-627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini622 – 68160KH
Add
BLAST
Domaini693 – 76270S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1VDC1-1 [UniParc]FASTAAdd to Basket

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MKGRGTHAMS SKKNNLPKNV SVEMVDPDAG IWEATATIDN GDFGSRTLRF    50
ETGLLARQAD GAVTAYLDED TILLSTTTAS RSPREGIDFF PLTVDVEERM 100
YSAGRIPGSF FRREGRPGTD AILAARLIDR PLRPTFVKGL RNEVQVVITV 150
MSIDPNEMYD VLAINGASAS TQLSGLPVSS SVGGVRMALV VDEEHPEGQW 200
VAFPTREQVS QSVFELVVAG RVTEPAKGGR GKKSQPNVAV MMVEAGATDN 250
VVERIAEGAP APTEAVVAEG IEAAKPFIAT LCAAQDALRD AVDTESREFE 300
LFPPFDEDVY SAVEAECDAD VAQIMTIADK QERDESLAEN MQETVDALIE 350
QFPERESEIR AAHNDLTRTI VRQRILEDGF RIDGRDHTSI RDLGIVVQLL 400
PRAHGSALFE RGETQILGVT TLDTLKMEQT IDSLGPETSK RYIHHYNFPP 450
YSTGETGRVG SPKRREIGHG ALAERALTPV LPSREEFPYT IRQVSEALGS 500
NGSTSMGSVC ASTLSLYNAG VPLKAPVAGI AMGLVSGLVD GKEKFVSLTD 550
ILGAEDAFGD MDFKVAGTSE YVTALQLDTK LDGLPSEVLA SALGQARSAR 600
LEILQLMEDA IDAPDQMSEL APRITKISIP QNKIGEVIGP KGKTINQITE 650
ETGANISIED DGTVFVSAVG GEAAEAAIEK INAIANPQQP KVGDRFLGTV 700
VKTTAFGAFI SLLPGRDGLL HISNIGGDRR IEKVEDELNV GDKIQVEIAD 750
IDNRGKISLV PVDED 765
Length:765
Mass (Da):82,266
Last modified:May 20, 2008 - v1
Checksum:i35F3EC377B492883
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942444 Genomic DNA. Translation: CAQ04819.1.
RefSeqiYP_001800253.1. NC_010545.1.

Genome annotation databases

EnsemblBacteriaiCAQ04819; CAQ04819; cu0859.
GeneIDi6184815.
KEGGicur:cur_0859.
PATRICi21521446. VBICorUre58120_0859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942444 Genomic DNA. Translation: CAQ04819.1 .
RefSeqi YP_001800253.1. NC_010545.1.

3D structure databases

ProteinModelPortali B1VDC1.
SMRi B1VDC1. Positions 34-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 504474.cur_0859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ04819 ; CAQ04819 ; cu0859 .
GeneIDi 6184815.
KEGGi cur:cur_0859.
PATRICi 21521446. VBICorUre58120_0859.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CURE504474:GJ8Y-875-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
    Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
    J. Biotechnol. 136:11-21(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43042 / DSM 7109.

Entry informationi

Entry nameiPNP_CORU7
AccessioniPrimary (citable) accession number: B1VDC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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