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B1VDC1

- PNP_CORU7

UniProt

B1VDC1 - PNP_CORU7

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi556 – 5561MagnesiumUniRule annotation
    Metal bindingi562 – 5621MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciCURE504474:GJ8Y-875-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:cu0859
    OrganismiCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
    Taxonomic identifieri504474 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000001727: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 765765Polyribonucleotide nucleotidyltransferasePRO_0000381880Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi504474.cur_0859.

    Structurei

    3D structure databases

    ProteinModelPortaliB1VDC1.
    SMRiB1VDC1. Positions 34-627.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini622 – 68160KHUniRule annotationAdd
    BLAST
    Domaini693 – 76270S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1VDC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGRGTHAMS SKKNNLPKNV SVEMVDPDAG IWEATATIDN GDFGSRTLRF    50
    ETGLLARQAD GAVTAYLDED TILLSTTTAS RSPREGIDFF PLTVDVEERM 100
    YSAGRIPGSF FRREGRPGTD AILAARLIDR PLRPTFVKGL RNEVQVVITV 150
    MSIDPNEMYD VLAINGASAS TQLSGLPVSS SVGGVRMALV VDEEHPEGQW 200
    VAFPTREQVS QSVFELVVAG RVTEPAKGGR GKKSQPNVAV MMVEAGATDN 250
    VVERIAEGAP APTEAVVAEG IEAAKPFIAT LCAAQDALRD AVDTESREFE 300
    LFPPFDEDVY SAVEAECDAD VAQIMTIADK QERDESLAEN MQETVDALIE 350
    QFPERESEIR AAHNDLTRTI VRQRILEDGF RIDGRDHTSI RDLGIVVQLL 400
    PRAHGSALFE RGETQILGVT TLDTLKMEQT IDSLGPETSK RYIHHYNFPP 450
    YSTGETGRVG SPKRREIGHG ALAERALTPV LPSREEFPYT IRQVSEALGS 500
    NGSTSMGSVC ASTLSLYNAG VPLKAPVAGI AMGLVSGLVD GKEKFVSLTD 550
    ILGAEDAFGD MDFKVAGTSE YVTALQLDTK LDGLPSEVLA SALGQARSAR 600
    LEILQLMEDA IDAPDQMSEL APRITKISIP QNKIGEVIGP KGKTINQITE 650
    ETGANISIED DGTVFVSAVG GEAAEAAIEK INAIANPQQP KVGDRFLGTV 700
    VKTTAFGAFI SLLPGRDGLL HISNIGGDRR IEKVEDELNV GDKIQVEIAD 750
    IDNRGKISLV PVDED 765
    Length:765
    Mass (Da):82,266
    Last modified:May 20, 2008 - v1
    Checksum:i35F3EC377B492883
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942444 Genomic DNA. Translation: CAQ04819.1.
    RefSeqiYP_001800253.1. NC_010545.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ04819; CAQ04819; cu0859.
    GeneIDi6184815.
    KEGGicur:cur_0859.
    PATRICi21521446. VBICorUre58120_0859.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942444 Genomic DNA. Translation: CAQ04819.1 .
    RefSeqi YP_001800253.1. NC_010545.1.

    3D structure databases

    ProteinModelPortali B1VDC1.
    SMRi B1VDC1. Positions 34-627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 504474.cur_0859.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ04819 ; CAQ04819 ; cu0859 .
    GeneIDi 6184815.
    KEGGi cur:cur_0859.
    PATRICi 21521446. VBICorUre58120_0859.

    Phylogenomic databases

    eggNOGi COG1185.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci CURE504474:GJ8Y-875-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 1 hit.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
      Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
      J. Biotechnol. 136:11-21(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43042 / DSM 7109.

    Entry informationi

    Entry nameiPNP_CORU7
    AccessioniPrimary (citable) accession number: B1VDC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3