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B1VDC1

- PNP_CORU7

UniProt

B1VDC1 - PNP_CORU7

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi556 – 5561MagnesiumUniRule annotation
Metal bindingi562 – 5621MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCURE504474:GJ8Y-875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:cu0859
OrganismiCorynebacterium urealyticum (strain ATCC 43042 / DSM 7109)
Taxonomic identifieri504474 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001727: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Polyribonucleotide nucleotidyltransferasePRO_0000381880Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi504474.cur_0859.

Structurei

3D structure databases

ProteinModelPortaliB1VDC1.
SMRiB1VDC1. Positions 34-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini622 – 68160KHUniRule annotationAdd
BLAST
Domaini693 – 76270S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1VDC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGRGTHAMS SKKNNLPKNV SVEMVDPDAG IWEATATIDN GDFGSRTLRF
60 70 80 90 100
ETGLLARQAD GAVTAYLDED TILLSTTTAS RSPREGIDFF PLTVDVEERM
110 120 130 140 150
YSAGRIPGSF FRREGRPGTD AILAARLIDR PLRPTFVKGL RNEVQVVITV
160 170 180 190 200
MSIDPNEMYD VLAINGASAS TQLSGLPVSS SVGGVRMALV VDEEHPEGQW
210 220 230 240 250
VAFPTREQVS QSVFELVVAG RVTEPAKGGR GKKSQPNVAV MMVEAGATDN
260 270 280 290 300
VVERIAEGAP APTEAVVAEG IEAAKPFIAT LCAAQDALRD AVDTESREFE
310 320 330 340 350
LFPPFDEDVY SAVEAECDAD VAQIMTIADK QERDESLAEN MQETVDALIE
360 370 380 390 400
QFPERESEIR AAHNDLTRTI VRQRILEDGF RIDGRDHTSI RDLGIVVQLL
410 420 430 440 450
PRAHGSALFE RGETQILGVT TLDTLKMEQT IDSLGPETSK RYIHHYNFPP
460 470 480 490 500
YSTGETGRVG SPKRREIGHG ALAERALTPV LPSREEFPYT IRQVSEALGS
510 520 530 540 550
NGSTSMGSVC ASTLSLYNAG VPLKAPVAGI AMGLVSGLVD GKEKFVSLTD
560 570 580 590 600
ILGAEDAFGD MDFKVAGTSE YVTALQLDTK LDGLPSEVLA SALGQARSAR
610 620 630 640 650
LEILQLMEDA IDAPDQMSEL APRITKISIP QNKIGEVIGP KGKTINQITE
660 670 680 690 700
ETGANISIED DGTVFVSAVG GEAAEAAIEK INAIANPQQP KVGDRFLGTV
710 720 730 740 750
VKTTAFGAFI SLLPGRDGLL HISNIGGDRR IEKVEDELNV GDKIQVEIAD
760
IDNRGKISLV PVDED
Length:765
Mass (Da):82,266
Last modified:May 20, 2008 - v1
Checksum:i35F3EC377B492883
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942444 Genomic DNA. Translation: CAQ04819.1.
RefSeqiYP_001800253.1. NC_010545.1.

Genome annotation databases

EnsemblBacteriaiCAQ04819; CAQ04819; cu0859.
GeneIDi6184815.
KEGGicur:cur_0859.
PATRICi21521446. VBICorUre58120_0859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942444 Genomic DNA. Translation: CAQ04819.1 .
RefSeqi YP_001800253.1. NC_010545.1.

3D structure databases

ProteinModelPortali B1VDC1.
SMRi B1VDC1. Positions 34-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 504474.cur_0859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ04819 ; CAQ04819 ; cu0859 .
GeneIDi 6184815.
KEGGi cur:cur_0859.
PATRICi 21521446. VBICorUre58120_0859.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CURE504474:GJ8Y-875-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing."
    Tauch A., Trost E., Tilker A., Ludewig U., Schneiker S., Goesmann A., Arnold W., Bekel T., Brinkrolf K., Brune I., Goetker S., Kalinowski J., Kamp P.-B., Lobo F.P., Viehoever P., Weisshaar B., Soriano F., Droege M., Puehler A.
    J. Biotechnol. 136:11-21(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43042 / DSM 7109.

Entry informationi

Entry nameiPNP_CORU7
AccessioniPrimary (citable) accession number: B1VDC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3