Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Phytoplasma australiense
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei217ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHY59748:G1GJW-461-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PA0498
OrganismiPhytoplasma australiense
Taxonomic identifieri59748 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeCandidatus Phytoplasma16SrXII (Stolbur group)
Proteomesi
  • UP000008323 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677361 – 448Glutamate--tRNA ligaseAdd BLAST448

Proteomic databases

PRIDEiB1VA59

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi59748.PAa_0498

Structurei

3D structure databases

ProteinModelPortaliB1VA59
SMRiB1VA59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi214 – 218"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
KOiK01885
OMAiHYINTLP

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1VA59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIRVRYAP SPTGFLHIGN ARTALFNYLF AKHHQGDFIL RIEDTDLLRN
60 70 80 90 100
VADGEASQLK NLRWLGIDWK EGPDINGPFG PYRQSERLTI YQKYAFELLE
110 120 130 140 150
KNLAYRDFEK DKKNFAIRFK VPPNQTFTFC DLIRGKLTFL SKEIEDWVII
160 170 180 190 200
KSNGYPSYNF AASIDDHLMQ ISHIFRGEEH ITNTPKQIMI YQSFNWSIPK
210 220 230 240 250
FAHMTLILNQ ERKKLSKRDV NVCQFIQDYA DLGYLPQSLF NFLSLLGFSP
260 270 280 290 300
SSCKEILTPQ EIISLFDVNR LNKSPAIFDK TKLDFFNNHY LRKTPIDDIV
310 320 330 340 350
SFIKTKLDFF EVLPINNQKW LTKFILLFQE RINYIKQLKD LYHHFFDKNT
360 370 380 390 400
SLSEEVEQFL KKHDCALSVL TLFYHKLNLV VFEKEAINPI IAEIAQNMKI
410 420 430 440
NKKNLFVILR IGATHKMQGP SLALFLELLG KKQVLNNLSK IVELLKNQ
Length:448
Mass (Da):52,517
Last modified:May 20, 2008 - v1
Checksum:iCE15060913FEDAC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM422018 Genomic DNA Translation: CAM11832.1
RefSeqiWP_012358971.1, NC_010544.1

Genome annotation databases

KEGGipal:PA0498

Similar proteinsi

Entry informationi

Entry nameiSYE_PHYAS
AccessioniPrimary (citable) accession number: B1VA59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health