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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Clostridium perfringens B str. ATCC 3626
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
ORF Names:AC1_2348Imported
OrganismiClostridium perfringens B str. ATCC 3626Imported
Taxonomic identifieri451754 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000004342 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalUniRule annotationAdd BLAST23
Transmembranei55 – 78HelicalUniRule annotationAdd BLAST24
Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 135HelicalUniRule annotationAdd BLAST20
Transmembranei147 – 166HelicalUniRule annotationAdd BLAST20
Transmembranei178 – 197HelicalUniRule annotationAdd BLAST20
Transmembranei203 – 222HelicalUniRule annotationAdd BLAST20
Transmembranei229 – 249HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 277HelicalUniRule annotationAdd BLAST23
Transmembranei304 – 322HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1R8V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEILKSMIDP KIVMAIVISF IVASILGPII IPLLHKLKFG QNIRQEGPKS
60 70 80 90 100
HLKKAGTPTI GGLIFIFATI ITMFIMVGNP TDEAMIALYS FVGFGFVGFL
110 120 130 140 150
DDLLKIIKKK NEGLTSGQKM ILLLIVSGFL TWYAYKYIGT SINIPFLNGQ
160 170 180 190 200
INFGLFYIPF VMFYFAGVTN AVNLTDGLDG LATSVTVLVT TFLGIISYNL
210 220 230 240 250
GHISLAIFCV ALAGALLAFL RFNAFPARVF MGDTGSLALG GAVAMVALIL
260 270 280 290 300
KMPLILVLIG IIYVIETLSV ILQVASFKLT GKRIFKMAPI HHHFEQLGWS
310 320
ETKIVSVFSI ITVVFCFIAF ASL
Length:323
Mass (Da):35,204
Last modified:May 20, 2008 - v1
Checksum:i6000B7E209CD82D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABDV01000019 Genomic DNA Translation: EDT23276.1
RefSeqiWP_003458662.1, NZ_ABDV01000019.1

Genome annotation databases

EnsemblBacteriaiEDT23276; EDT23276; AC1_2348
GeneIDi29570781

Entry informationi

Entry nameiB1R8V0_CLOPF
AccessioniPrimary (citable) accession number: B1R8V0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 27, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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