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Protein

Ghrelin O-acyltransferase

Gene

Mboat4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei307By similarity1
Active sitei338By similarity1

GO - Molecular functioni

  • serine O-acyltransferase activity Source: UniProtKB

GO - Biological processi

  • peptidyl-serine octanoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Ghrelin O-acyltransferase1 Publication (EC:2.3.1.-)
Alternative name(s):
Membrane-bound O-acyltransferase domain-containing protein 4Imported
Gene namesi
Name:Mboat4Imported
Synonyms:Goat1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1566335. Mboat4.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472771 – 435Ghrelin O-acyltransferaseAdd BLAST435

Proteomic databases

PaxDbiB1Q005.
PRIDEiB1Q005.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046106.

Family & Domainsi

Sequence similaritiesi

Belongs to the membrane-bound acyltransferase family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2704. Eukaryota.
COG5202. LUCA.
GeneTreeiENSGT00550000074565.
HOGENOMiHOG000113492.
HOVERGENiHBG108120.
InParanoidiB1Q005.
OMAiAFSAWWH.
OrthoDBiEOG091G07L0.
PhylomeDBiB1Q005.
TreeFamiTF314906.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1Q005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWLQFFFLH PVSLYQGAAF PFALLFNYLC ITESFPTRAR YLFLLAGGGV
60 70 80 90 100
LALAAMGPYA LLIFIPALCA VAMISSLSPQ EVHGLTFFFQ MGWQTLCHLG
110 120 130 140 150
LHYKEYYLCE PPPVRFYITL SSLMLLTQRV TSLSLDISEG KVEAAWRGTR
160 170 180 190 200
SRSSLCEHLW DALPYISYLL FFPALLGGSL CSFQRFQACV QRPRSLYPSI
210 220 230 240 250
SFWALTWRGL QILGLECLKV ALRRVVSAGA GLDDCQRLEC IYIMWSTAGL
260 270 280 290 300
FKLTYYSHWI LDDSLLHAAG FGSEAGQRPG EERYVPDVDI WTLETTHRIS
310 320 330 340 350
LFARQWNRST AQWLKRLVFQ RSRRWPVLQT FAFSAWWHGL HPGQVFGFLC
360 370 380 390 400
WSVMVKADYL IHTFANGCIR SWPLRLLYRS LTWAHTQIII AYVMLAVEGR
410 420 430
SFSSLCRLCC SYNSIFPVTY CLLLFLLARR KHKCN
Length:435
Mass (Da):50,008
Last modified:April 29, 2008 - v1
Checksum:iFD6B293FDEA44115
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU518497 mRNA. Translation: ACB05875.1.
RefSeqiNP_001100787.2. NM_001107317.2.
XP_017455622.1. XM_017600133.1.
UniGeneiRn.218502.

Genome annotation databases

EnsembliENSRNOT00000042003; ENSRNOP00000046106; ENSRNOG00000030102.
GeneIDi306515.
KEGGirno:306515.
UCSCiRGD:1566335. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU518497 mRNA. Translation: ACB05875.1.
RefSeqiNP_001100787.2. NM_001107317.2.
XP_017455622.1. XM_017600133.1.
UniGeneiRn.218502.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046106.

Proteomic databases

PaxDbiB1Q005.
PRIDEiB1Q005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042003; ENSRNOP00000046106; ENSRNOG00000030102.
GeneIDi306515.
KEGGirno:306515.
UCSCiRGD:1566335. rat.

Organism-specific databases

CTDi619373.
RGDi1566335. Mboat4.

Phylogenomic databases

eggNOGiKOG2704. Eukaryota.
COG5202. LUCA.
GeneTreeiENSGT00550000074565.
HOGENOMiHOG000113492.
HOVERGENiHBG108120.
InParanoidiB1Q005.
OMAiAFSAWWH.
OrthoDBiEOG091G07L0.
PhylomeDBiB1Q005.
TreeFamiTF314906.

Enzyme and pathway databases

ReactomeiR-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

PROiB1Q005.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMBOA4_RAT
AccessioniPrimary (citable) accession number: B1Q005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.