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Protein

Movement and silencing protein TGBp1

Gene

ORF2

Organism
Lolium latent virus (isolate Lolium/USA/US1/-) (LoLV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).By similarity

Miscellaneous

TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-cell propagation. TGBp1 is the main movement protein that physically cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would facilitate TGBp1 function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement and silencing protein TGBp1
Alternative name(s):
25 kDa protein
Silencing suppressor P25
Triple gene block 1 protein
Short name:
TGBp1
Gene namesi
Name:ORF2
OrganismiLolium latent virus (isolate Lolium/USA/US1/-) (LoLV)
Taxonomic identifieri686945 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaeLolavirus
Virus hostiLolium multiflorum x Lolium perenne [TaxID: 480553]
Proteomesi
  • UP000008689 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004010741 – 268Movement and silencing protein TGBp1Add BLAST268

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with capsid protein. Interacts with host AGO1; this interaction targets the host protein for degradation, thereby suppressing the antiviral RNA silencing (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 138(+)RNA virus helicase ATP-bindingAdd BLAST138
Domaini139 – 268(+)RNA virus helicase C-terminalAdd BLAST130

Sequence similaritiesi

Belongs to the Tymovirales TGBp1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000NV.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01443. Viral_helicase1. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51657. PSRV_HELICASE. 1 hit.

Sequencei

Sequence statusi: Complete.

B1PS77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDFFNCLRS RGFERTDEPL PSDSRRIVVH GVGGSGKTSL IEAFAIANEW
60 70 80 90 100
VRAYTLTSHE RFDISGRGIS QYKGQPIDEK LWTILDEYGQ TDNPETLPPF
110 120 130 140 150
NVLATDPYQA FRCQPLRAHF VSLRSYRVPH HIAQAITQYT GFPIEAAGTD
160 170 180 190 200
LHEGKYTVGP WTDKLRQQIL VEDGEIHYQL SRRQCPHKLI TDAIGEQWPT
210 220 230 240 250
VTVVFDRSIS PESARPLRCL FYIAATRSSN ELNIRTYVPT RTPGLIKASL
260
PHTSCRLCCR PRDLPSEN
Length:268
Mass (Da):30,474
Last modified:April 29, 2008 - v1
Checksum:iF3F9BB1979C6E4A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU489641 Genomic RNA. Translation: ACA53375.1.
RefSeqiYP_001718500.1. NC_010434.1.

Genome annotation databases

GeneIDi6000102.
KEGGivg:6000102.

Entry informationi

Entry nameiTGB1_LOLV
AccessioniPrimary (citable) accession number: B1PS77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: April 29, 2008
Last modified: March 15, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families