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Protein

Caveolae-associated protein 4

Gene

Cavin4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 4Imported
Alternative name(s):
Muscle-related coiled-coil proteinBy similarity
Muscle-restricted coiled-coil proteinImported
Gene namesi
Name:Cavin4Imported
Synonyms:MurcImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1310395 Cavin4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003702211 – 362Caveolae-associated protein 4Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei324PhosphotyrosineBy similarity1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei353PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB1PRL5
PeptideAtlasiB1PRL5
PRIDEiB1PRL5

PTM databases

iPTMnetiB1PRL5
PhosphoSitePlusiB1PRL5

Expressioni

Tissue specificityi

Expressed at much higher levels in cardiomyocytes than in non-cardiomyocytes.1 Publication

Gene expression databases

BgeeiENSRNOG00000008027
GenevisibleiB1PRL5 RN

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with CAVIN1, CAV3, ADRA1A and ADRA1B. Interacts with CAVIN2; this augments the transactivation of NPPA (By similarity). Interacts with MAPK1 and MAPK3 (PubMed:24567387).By similarity1 Publication

Structurei

3D structure databases

SMRiB1PRL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 120Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGHQ Eukaryota
ENOG411021K LUCA
GeneTreeiENSGT00530000063058
HOGENOMiHOG000293135
InParanoidiB1PRL5
OMAiHSNTGHI
OrthoDBiEOG091G09Y1
PhylomeDBiB1PRL5
TreeFamiTF331031

Family and domain databases

InterProiView protein in InterPro
IPR033299 Cavin4
IPR026752 Cavin_fam
PANTHERiPTHR15240 PTHR15240, 1 hit
PTHR15240:SF4 PTHR15240:SF4, 1 hit
PfamiView protein in Pfam
PF15237 PTRF_SDPR, 1 hit

Sequencei

Sequence statusi: Complete.

B1PRL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHNGSASNA GKIHQNRLSS VTEDEDQDAA LTIVTVLDRV ATVVDSVQAS
60 70 80 90 100
QKRIEERHRE MGNAIKSVQI DLLKLSQSHS NTGYVVNKLF EKTRKVSAHI
110 120 130 140 150
KDVKARVEKQ QVRVTKVETK QEEIMKKNKF RVVIFQEDVP CPASLSVVKD
160 170 180 190 200
RSLPENEEEA EEVFDPPIDL SSDEEYYVEE SRSARLRKSG KEHIDHIKKA
210 220 230 240 250
FSKENMQKTR QNFDKKVSGI RTRIVTPERR ERLRQSGERL RQSGERLRQS
260 270 280 290 300
GERFKKSISN ATPSKEAFKI RSLRKPKDPK AEGQEVDRGM GVDIISGSLA
310 320 330 340 350
LGPIHEFHSD GFSETEKEVT KVGYIPQEGG DPPTPEPLKV TFKPQVRVED
360
DESLLLELKQ SS
Length:362
Mass (Da):41,093
Last modified:April 29, 2008 - v1
Checksum:iC3FB53E5D7D9C154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU487255 mRNA Translation: ACA62937.1
RefSeqiNP_001101401.1, NM_001107931.2
UniGeneiRn.218700

Genome annotation databases

EnsembliENSRNOT00000010561; ENSRNOP00000010561; ENSRNOG00000008027
GeneIDi313225
KEGGirno:313225
UCSCiRGD:1310395 rat

Similar proteinsi

Entry informationi

Entry nameiCAVN4_RAT
AccessioniPrimary (citable) accession number: B1PRL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health