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Protein

Gap junction protein

Gene

Gja8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotationSAAS annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
Gene namesi
Name:Gja8Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei78 – 97HelicalSequence analysisAdd BLAST20
Transmembranei158 – 179HelicalSequence analysisAdd BLAST22
Transmembranei211 – 229HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 76CNXInterPro annotationAdd BLAST34
Domaini168 – 234Connexin_CCCInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the connexin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.
HOVERGENiHBG009576.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF19. PTHR11984:SF19. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B1PL11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS
60 70 80 90 100
DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL MYVGHAVHHV
110 120 130 140 150
RMEEKRKDRE AEELCQQSRS NGGERVPIAP DQASIRKSSS SSKGTKKFRL
160 170 180 190 200
EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD
210 220 230 240 250
CFVSRPTEKT IFILFMLSVA FVSLFLNIME MSHLGMKGIR SAFKRPAEQP
260 270 280 290 300
LGEIAEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVETSPLS
310 320 330 340 350
AKPFSQFEEK IGTGPLADMS RGYQETLPSY AQVGAQEVER EEQPVEEAVE
360 370 380 390 400
PELGEKKQEA EKVAPEGQET VAVPDGEKVE TPGVGKDDEK EELQAEKVTK
410 420 430 440
QGLSAEKAPT LCPELTTDDN RPLSRLSKAS SRARSDDLTI
Length:440
Mass (Da):49,415
Last modified:April 29, 2008 - v1
Checksum:i67EEDA2775AA16BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445789 Genomic DNA. Translation: ACA49112.1.
EU445791 Genomic DNA. Translation: ACA49114.1.
UniGeneiRn.86658.

Similar proteinsi

Entry informationi

Entry nameiB1PL11_RAT
AccessioniPrimary (citable) accession number: B1PL11
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 25, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)