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Protein
Submitted name:

MHC class I antigen

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-AImported
Synonyms:HLAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000206503.11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501120333625 – 365Sequence analysisAdd BLAST341

Expressioni

Gene expression databases

BgeeiENSG00000206503.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di1.20.5.100. 1 hit.
2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR037055. MHC_I-like_Ag-recog_sf.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

B1PKY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,841
Last modified:April 29, 2008 - v1
Checksum:iDEDFCEC4450E0580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445472 Genomic DNA. Translation: ACA34992.1.
GU812296 Genomic DNA. Translation: ADE80887.1.
KT156722 Genomic DNA. Translation: ALO24306.1.
KT266701 Genomic DNA. Translation: ALP46208.1.
KT266702 Genomic DNA. Translation: ALP46209.1.
KU528595 Genomic DNA. Translation: ALZ40810.1.
KT819308 Genomic DNA. Translation: AMO26194.1.
KX962567 Genomic DNA. Translation: APO40931.1.
KY072923 Genomic DNA. Translation: AQN67170.1.
KX583634 Genomic DNA. Translation: ARX77874.1.
KX686515 Genomic DNA. Translation: ARX98023.1.
KY235394 Genomic DNA. Translation: ASA47542.1.
KY368782 Genomic DNA. Translation: ASA47563.1.
KY368783 Genomic DNA. Translation: ASA47564.1.
KY419437 Genomic DNA. Translation: ASU50328.1.
KY419438 Genomic DNA. Translation: ASU50329.1.
MF474221 Genomic DNA. Translation: ASU61671.1.
MF474222 Genomic DNA. Translation: ASU61672.1.
AB774956 Genomic DNA. Translation: BAN59802.1.
AB774974 Genomic DNA. Translation: BAN59820.1.
HG327114 mRNA. Translation: CDG23669.1.
HG794390 Genomic DNA. Translation: CDK41199.1.
HG794396 Genomic DNA. Translation: CDK41205.1.
LN877322 Genomic DNA. Translation: CUA55065.1.
LN994612 Genomic DNA. Translation: CUV66664.1.
LN994664 Genomic DNA. Translation: CUV66716.1.
LN994669 Genomic DNA. Translation: CUV66721.1.
LN994733 Genomic DNA. Translation: CUV66785.1.
LN999578 Genomic DNA. Translation: CUX90971.1.
LN999594 Genomic DNA. Translation: CUX90987.1.
LT219465 Genomic DNA. Translation: CZQ50133.1.
LT546644 Genomic DNA. Translation: SAI65262.1.
LT599184 Genomic DNA. Translation: SBW38405.1.
LT827023 Genomic DNA. Translation: SLM20096.1.
LT898182 Genomic DNA. Translation: SNQ25992.1.
RefSeqiNP_002107.3. NM_002116.7.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

GeneIDi3105.

Similar proteinsi

Entry informationi

Entry nameiB1PKY1_HUMAN
AccessioniPrimary (citable) accession number: B1PKY1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 22, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.