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Protein
Submitted name:

MHC Class I Antigen

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC Class I AntigenImported
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 365341Sequence analysisPRO_5007638419Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366005.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1PKY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,841
Last modified:April 29, 2008 - v1
Checksum:iDEDFCEC4450E0580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445472 Genomic DNA. Translation: ACA34992.1.
GU812296 Genomic DNA. Translation: ADE80887.1.
KT156722 Genomic DNA. Translation: ALO24306.1.
KT266701 Genomic DNA. Translation: ALP46208.1.
KT266702 Genomic DNA. Translation: ALP46209.1.
KU528595 Genomic DNA. Translation: ALZ40810.1.
KT819308 Genomic DNA. Translation: AMO26194.1.
AB774956 Genomic DNA. Translation: BAN59802.1.
AB774974 Genomic DNA. Translation: BAN59820.1.
HG327114 mRNA. Translation: CDG23669.1.
HG794390 Genomic DNA. Translation: CDK41199.1.
HG794396 Genomic DNA. Translation: CDK41205.1.
LN994612 Genomic DNA. Translation: CUV66664.1.
LN994664 Genomic DNA. Translation: CUV66716.1.
LN994669 Genomic DNA. Translation: CUV66721.1.
LN994733 Genomic DNA. Translation: CUV66785.1.
LN999578 Genomic DNA. Translation: CUX90971.1.
LN999594 Genomic DNA. Translation: CUX90987.1.
LT219465 Genomic DNA. Translation: CZQ50133.1.
LT546644 Genomic DNA. Translation: SAI65262.1.
RefSeqiNP_002107.3. NM_002116.7.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

GeneIDi3105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445472 Genomic DNA. Translation: ACA34992.1.
GU812296 Genomic DNA. Translation: ADE80887.1.
KT156722 Genomic DNA. Translation: ALO24306.1.
KT266701 Genomic DNA. Translation: ALP46208.1.
KT266702 Genomic DNA. Translation: ALP46209.1.
KU528595 Genomic DNA. Translation: ALZ40810.1.
KT819308 Genomic DNA. Translation: AMO26194.1.
AB774956 Genomic DNA. Translation: BAN59802.1.
AB774974 Genomic DNA. Translation: BAN59820.1.
HG327114 mRNA. Translation: CDG23669.1.
HG794390 Genomic DNA. Translation: CDK41199.1.
HG794396 Genomic DNA. Translation: CDK41205.1.
LN994612 Genomic DNA. Translation: CUV66664.1.
LN994664 Genomic DNA. Translation: CUV66716.1.
LN994669 Genomic DNA. Translation: CUV66721.1.
LN994733 Genomic DNA. Translation: CUV66785.1.
LN999578 Genomic DNA. Translation: CUX90971.1.
LN999594 Genomic DNA. Translation: CUX90987.1.
LT219465 Genomic DNA. Translation: CZQ50133.1.
LT546644 Genomic DNA. Translation: SAI65262.1.
RefSeqiNP_002107.3. NM_002116.7.
UniGeneiHs.181244.
Hs.713441.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366005.

Protocols and materials databases

DNASUi3105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3105.

Organism-specific databases

CTDi3105.
PharmGKBiPA35055.

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.

Miscellaneous databases

ChiTaRSiHLA-A. human.
GenomeRNAii3105.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the complete genomic sequence of HLA-A alleles in the Chinese Han population."
    Zhu F., He Y., Zhang W., He J., He J., Xu X., Yan L.
    Int. J. Immunogenet. 36:351-360(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Characterization and polymorphism analyses of HLA-A genomic full length in Chinese Han population."
    Xu Y.P., Deng Z.H., Yang B.C.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
    Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
    BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Voorter C.
    Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.
  5. "Identification of full length polymorphism of HLA class I by an RNA approach on peripheral blood lymphocytes."
    Gerritsen K.E.H., Groeneweg M., Olieslagers T.I., Palusci F., Crijns V.B.G., Voorter C.E.M., Tilanus M.G.J.
    Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.
  6. "Confirmatory sequencing of HLA-A*03:01:01:01."
    McWhinnie A.J., Robinson J.
    Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Peripheral bloodImported and Saliva collectionImported.
  7. "Novel HLA class I allele."
    Lazaro A.M., Masaberg C., Hou L., Hurley C.K.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. Noorani M.
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Novel HLA class I allele."
    Lazaro A.M., Hou L., Hurley C.K.
    Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
    Albrecht V., Boehme I., Schmidt A.H.
    Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
    Albrecht V., Boehme I., Schmidt A.H.
    Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "Generation of high confidence HLA genotyping and consensus sequences for Class I HLA loci using the NGS-based Omixon Holotype HLA typing system and the Illumina MiSeq platform."
    Bravo-Egana V., Clark P., Monos D.
    Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. "Novel HLA-A*03:01:new allele."
    Zakharova V.V.
    Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Peripheral bloodImported.
  14. Wen L., He K., Yang H.
    Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Peripheral bloodImported.
  15. "Novel HLA-A*03:01:new allele."
    Zakharova V.V.
    Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB1PKY1_HUMAN
AccessioniPrimary (citable) accession number: B1PKY1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.