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Protein
Submitted name:

ICSU

Gene

ISCU

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ICSUImported
Submitted name:
ISCUImported
Gene namesi
Name:ISCUImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiB1P7G3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310623.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 115105NifU_NInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG3361. Eukaryota.
COG0822. LUCA.
HOGENOMiHOG000069228.
HOVERGENiHBG052621.

Family and domain databases

InterProiIPR002871. NIF_FeS_clus_asmbl_NifU_N.
[Graphical view]
PfamiPF01592. NifU_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1P7G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLIDMSVDL STQVVDHYEN PRNVGSLDKT SKNVGTGLVG APACGDVMKL
60 70 80 90 100
QIQVDEKGKI VDARFKTFGC GSAIASSSLA TEWVKGKTVE EALTIKNTDI
110 120
AKELCLPPVK LHCSKSVLFP AEEKTQLSP
Length:129
Mass (Da):13,819
Last modified:April 29, 2008 - v1
Checksum:iABF807378E01C0D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU329002 mRNA. Translation: ACA34743.1.
EU334585 Genomic DNA. Translation: ACA52543.1.
RefSeqiXP_011536402.1. XM_011538100.1.
UniGeneiHs.615131.

Genome annotation databases

GeneIDi23479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU329002 mRNA. Translation: ACA34743.1.
EU334585 Genomic DNA. Translation: ACA52543.1.
RefSeqiXP_011536402.1. XM_011538100.1.
UniGeneiHs.615131.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310623.

Proteomic databases

PeptideAtlasiB1P7G3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23479.

Organism-specific databases

CTDi23479.

Phylogenomic databases

eggNOGiKOG3361. Eukaryota.
COG0822. LUCA.
HOGENOMiHOG000069228.
HOVERGENiHBG052621.

Miscellaneous databases

ChiTaRSiISCU. human.
GenomeRNAii23479.

Family and domain databases

InterProiIPR002871. NIF_FeS_clus_asmbl_NifU_N.
[Graphical view]
PfamiPF01592. NifU_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance."
    Mochel F., Knight M.A., Tong W.-H., Hernandez D., Ayyad K., Taivassalo T., Andersen P.M., Singleton A., Rouault T.A., Fischbeck K.H., Haller R.G.
    Am. J. Hum. Genet. 82:652-660(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB1P7G3_HUMAN
AccessioniPrimary (citable) accession number: B1P7G3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.