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B1P3E1

- B1P3E1_ACIBI

UniProt

B1P3E1 - B1P3E1_ACIBI

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Protein
Submitted name: Diketoreductase
Gene
dkr
Organism
Acinetobacter baylyi
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADImported
Binding sitei75 – 751Phosphate 2Imported
Binding sitei100 – 1001NADImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADImported
Nucleotide bindingi94 – 952NADImported
Nucleotide bindingi120 – 1223NADImported

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: InterPro
  2. NAD+ binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

NADImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
DiketoreductaseImported
Gene namesi
Name:dkrImported
OrganismiAcinetobacter baylyiImported
Taxonomic identifieri202950 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DYDX-ray1.95A1-283[»]
4E12X-ray1.93A1-283[»]
4E13X-ray2.08A1-283[»]
ProteinModelPortaliB1P3E1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 412Phosphate 2 bindingImported
Regioni146 – 1472Phosphate 1 bindingImported

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

B1P3E1-1 [UniParc]FASTAAdd to Basket

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MTGITNVTVL GTGVLGSQIA FQTAFHGFAV TAYDINTDAL DAAKKRFEGL    50
AAVYEKEVAG AADGAAQKAL GGIRYSDDLA QAVKDADLVI EAVPESLDLK 100
RDIYTKLGEL APAKTIFATN SSTLLPSDLV GYTGRGDKFL ALHFANHVWV 150
NNTAEVMGTT KTDPEVYQQV VEFASAIGMV PIELKKEKAG YVLNSLLVPL 200
LDAAAELLVD GIADPETIDK TWRIGTGAPK GPFEIFDIVG LTTAYNISSV 250
SGPKQREFAA YLKENYIDKG KLGLATGEGF YRY 283
Length:283
Mass (Da):30,237
Last modified:April 29, 2008 - v1
Checksum:i275E6E9E18FDD09A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU273886 Genomic DNA. Translation: ABY48099.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU273886 Genomic DNA. Translation: ABY48099.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DYD X-ray 1.95 A 1-283 [» ]
4E12 X-ray 1.93 A 1-283 [» ]
4E13 X-ray 2.08 A 1-283 [» ]
ProteinModelPortali B1P3E1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR022694. 3-OHacyl-CoA_DH.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000105. HCDH. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and characterization of a novel diketoreductase from Acinetobacter baylyi."
    Wu X., Liu N., He Y., Chen Y.
    Acta Biochim. Biophys. Sin. 41:163-170(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 33305Imported.
  2. "Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase."
    Lu M., Huang Y., White M.A., Wu X., Liu N., Cheng X., Chen Y.
    Chem. Commun. (Camb.) 48:11352-11354(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) IN COMPLEX WITH NAD AND PHOSPHATE.

Entry informationi

Entry nameiB1P3E1_ACIBI
AccessioniPrimary (citable) accession number: B1P3E1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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