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B1P3E1

- B1P3E1_ACIBI

UniProt

B1P3E1 - B1P3E1_ACIBI

Protein
Submitted name:

Diketoreductase

Gene

dkr

Organism
Acinetobacter baylyi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADImported
    Binding sitei100 – 1001NADImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADImported
    Nucleotide bindingi94 – 952NADImported
    Nucleotide bindingi120 – 1223NADImported

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: InterPro
    2. NAD+ binding Source: InterPro

    GO - Biological processi

    1. fatty acid metabolic process Source: InterPro

    Keywords - Ligandi

    NADImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    DiketoreductaseImported
    Gene namesi
    Name:dkrImported
    OrganismiAcinetobacter baylyiImported
    Taxonomic identifieri202950 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DYDX-ray1.95A1-283[»]
    4E12X-ray1.93A1-283[»]
    4E13X-ray2.08A1-283[»]
    ProteinModelPortaliB1P3E1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR022694. 3-OHacyl-CoA_DH.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000105. HCDH. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1P3E1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGITNVTVL GTGVLGSQIA FQTAFHGFAV TAYDINTDAL DAAKKRFEGL    50
    AAVYEKEVAG AADGAAQKAL GGIRYSDDLA QAVKDADLVI EAVPESLDLK 100
    RDIYTKLGEL APAKTIFATN SSTLLPSDLV GYTGRGDKFL ALHFANHVWV 150
    NNTAEVMGTT KTDPEVYQQV VEFASAIGMV PIELKKEKAG YVLNSLLVPL 200
    LDAAAELLVD GIADPETIDK TWRIGTGAPK GPFEIFDIVG LTTAYNISSV 250
    SGPKQREFAA YLKENYIDKG KLGLATGEGF YRY 283
    Length:283
    Mass (Da):30,237
    Last modified:April 29, 2008 - v1
    Checksum:i275E6E9E18FDD09A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU273886 Genomic DNA. Translation: ABY48099.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU273886 Genomic DNA. Translation: ABY48099.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DYD X-ray 1.95 A 1-283 [» ]
    4E12 X-ray 1.93 A 1-283 [» ]
    4E13 X-ray 2.08 A 1-283 [» ]
    ProteinModelPortali B1P3E1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR022694. 3-OHacyl-CoA_DH.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000105. HCDH. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression, and characterization of a novel diketoreductase from Acinetobacter baylyi."
      Wu X., Liu N., He Y., Chen Y.
      Acta Biochim. Biophys. Sin. 41:163-170(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 33305Imported.
    2. "Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase."
      Lu M., Huang Y., White M.A., Wu X., Liu N., Cheng X., Chen Y.
      Chem. Commun. (Camb.) 48:11352-11354(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) IN COMPLEX WITH NAD.

    Entry informationi

    Entry nameiB1P3E1_ACIBI
    AccessioniPrimary (citable) accession number: B1P3E1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3