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B1NKT0

- VP2_ROTHP

UniProt

B1NKT0 - VP2_ROTHP

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain Human/United States/P/1974 G3-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus A (strain Human/United States/P/1974 G3-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
    Taxonomic identifieri10957 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007047: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 896896Inner capsid protein VP2PRO_0000368064Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 106106Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni410 – 43021HydrophobicBy similarityAdd
    BLAST
    Regioni438 – 45821HydrophobicBy similarityAdd
    BLAST
    Regioni552 – 57322Leucine-zipper 1Sequence AnalysisAdd
    BLAST
    Regioni681 – 70222Leucine-zipper 2Sequence AnalysisAdd
    BLAST

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    B1NKT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYRKRGVKR EDLPQQNERL QEKEIENNTD VTMENKDKNK NKNNNRKQQL    50
    SDKVLSQKEE IITDVQDDIK IADEVKKSSK EESKQLLEIL KTKEDHQKEV 100
    QYEILQKTIP TFEPKESILK KLEDIRPEQA KKQMKLFRIF EPRQLPIYRA 150
    NGEKELRNRW YWKLKKDTLP DGDYDVREYF LNLYDQILIE MPDYLLLKDM 200
    AVENKNSRDA GKVVDSETAS ICDAIFQDEE TEGVIRRFIA DMRQQVQADR 250
    NIVNYPSILH PIDHAFNEYF LNHQLVEPLN NEIIFNYIPE RIRNDVNYIL 300
    NMDMNLPSTA RYIRPNLLQD RLNLHDNFES LWDTITTSNY ILARSVVPDL 350
    KEKELVSTEA QIQKMSQDLQ LEALTIQSET QFLAGINSQA ANDCFKTLIA 400
    AMLSQRTMSL DFVTTNYMSL ISGMWLLTVI PNDMFLRESL VACELAIINT 450
    IVYPAFGMQR MHYRNGDPQT PFQIAEQQIQ NFQVANWLHF INNNRFRQVV 500
    IDGVLNQTLN DNIRNGQVIN QLMEALMQLS RQQFPTMPVD YKRSIQRGIL 550
    LLSNRLGQLV DLTRLLSYNY ETLMACITMN MQHVQTLTTE KLQLTSVTSL 600
    CMLIGNTTVI PSPQTLFHYY NVNVNFHSNY NERINDAVAI ITAANRLNLY 650
    QKKMKSIVED FLKRLQIFDV PRVPDDQMYR LRDRLRLLPV ERRRLDIFNL 700
    ILMNMEQIER ASDKIAQGVI IAYRDMQLER DEMYGFVNIA RNLDGYQQIN 750
    LEELMRTGDY GQITNMLLNN QPVALVGALP FVTDSSVISL IAKLDATVFA 800
    QIVKLRKVDT LKPILYKINS DSNDFYLVAN YDWIPTSTTK VYKQVPQPFD 850
    FRASMHMLTS NLTFTVYSDL LSFVSADTVE PINAIAFDNM RIMNEL 896
    Length:896
    Mass (Da):104,590
    Last modified:April 29, 2008 - v1
    Checksum:iC81C25191C38C575
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF583038 Genomic RNA. Translation: ABU87847.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF583038 Genomic RNA. Translation: ABU87847.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
      Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
      J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTHP
    AccessioniPrimary (citable) accession number: B1NKT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3