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B1NKT0

- VP2_ROTHP

UniProt

B1NKT0 - VP2_ROTHP

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Protein
Inner capsid protein VP2
Gene
N/A
Organism
Rotavirus A (strain Human/United States/P/1974 G3-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus A (strain Human/United States/P/1974 G3-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
Taxonomic identifieri10957 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007047: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 896896Inner capsid protein VP2
PRO_0000368064Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 106106Interaction with VP1 and VP3 By similarity
Add
BLAST
Regioni410 – 43021Hydrophobic By similarity
Add
BLAST
Regioni438 – 45821Hydrophobic By similarity
Add
BLAST
Regioni552 – 57322Leucine-zipper 1 Reviewed prediction
Add
BLAST
Regioni681 – 70222Leucine-zipper 2 Reviewed prediction
Add
BLAST

Domaini

The N-terminus is involved in VP1 binding By similarity.

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

B1NKT0-1 [UniParc]FASTAAdd to Basket

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MAYRKRGVKR EDLPQQNERL QEKEIENNTD VTMENKDKNK NKNNNRKQQL    50
SDKVLSQKEE IITDVQDDIK IADEVKKSSK EESKQLLEIL KTKEDHQKEV 100
QYEILQKTIP TFEPKESILK KLEDIRPEQA KKQMKLFRIF EPRQLPIYRA 150
NGEKELRNRW YWKLKKDTLP DGDYDVREYF LNLYDQILIE MPDYLLLKDM 200
AVENKNSRDA GKVVDSETAS ICDAIFQDEE TEGVIRRFIA DMRQQVQADR 250
NIVNYPSILH PIDHAFNEYF LNHQLVEPLN NEIIFNYIPE RIRNDVNYIL 300
NMDMNLPSTA RYIRPNLLQD RLNLHDNFES LWDTITTSNY ILARSVVPDL 350
KEKELVSTEA QIQKMSQDLQ LEALTIQSET QFLAGINSQA ANDCFKTLIA 400
AMLSQRTMSL DFVTTNYMSL ISGMWLLTVI PNDMFLRESL VACELAIINT 450
IVYPAFGMQR MHYRNGDPQT PFQIAEQQIQ NFQVANWLHF INNNRFRQVV 500
IDGVLNQTLN DNIRNGQVIN QLMEALMQLS RQQFPTMPVD YKRSIQRGIL 550
LLSNRLGQLV DLTRLLSYNY ETLMACITMN MQHVQTLTTE KLQLTSVTSL 600
CMLIGNTTVI PSPQTLFHYY NVNVNFHSNY NERINDAVAI ITAANRLNLY 650
QKKMKSIVED FLKRLQIFDV PRVPDDQMYR LRDRLRLLPV ERRRLDIFNL 700
ILMNMEQIER ASDKIAQGVI IAYRDMQLER DEMYGFVNIA RNLDGYQQIN 750
LEELMRTGDY GQITNMLLNN QPVALVGALP FVTDSSVISL IAKLDATVFA 800
QIVKLRKVDT LKPILYKINS DSNDFYLVAN YDWIPTSTTK VYKQVPQPFD 850
FRASMHMLTS NLTFTVYSDL LSFVSADTVE PINAIAFDNM RIMNEL 896
Length:896
Mass (Da):104,590
Last modified:April 29, 2008 - v1
Checksum:iC81C25191C38C575
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF583038 Genomic RNA. Translation: ABU87847.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF583038 Genomic RNA. Translation: ABU87847.1 .

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
    Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
    J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTHP
AccessioniPrimary (citable) accession number: B1NKT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 16, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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