SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B1NKR4

- VP2_ROTAD

UniProt

B1NKR4 - VP2_ROTAD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Inner capsid protein VP2
Gene
N/A
Organism
Rotavirus A (strain Human/United States/D/1974 G1-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus A (strain Human/United States/D/1974 G1-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
Taxonomic identifieri578831 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000006368: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Inner capsid protein VP2
PRO_0000368062Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 100100Interaction with VP1 and VP3 By similarity
Add
BLAST
Regioni404 – 42421Hydrophobic By similarity
Add
BLAST
Regioni432 – 45221Hydrophobic By similarity
Add
BLAST
Regioni546 – 56722Leucine-zipper 1 Reviewed prediction
Add
BLAST
Regioni675 – 69622Leucine-zipper 2 Reviewed prediction
Add
BLAST

Domaini

The N-terminus is involved in VP1 binding By similarity.

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

B1NKR4-1 [UniParc]FASTAAdd to Basket

« Hide

MAYRKRGAKR ENLPQQNERL QEKEIEKDVD VTMENKNNNR KQQLSDKVLS    50
QKEEIITDAQ DDIKIAGEIK KSSKEESKQL LEILKTKEDH QKEIQYEILQ 100
KTIPTFESKE SILKKLEDIR PEQAKKQMKL FRIFEPKQLP IYRANGEKEL 150
RNRWYWKLKK DTLPDGDYDV REYFLNLYDQ ILIEMPDYLL LKDMAVENKN 200
SRDAGKVVDS ETANICDAIF QDEETEGVVR RFIADMRQQV QADRNIVNYP 250
SILHPIDHAF NEYFLNHQLV EPLNNEIIFN YIPERIRNDV NYILNMDMNL 300
PSTARYIRPN LLQDRLNLHD NFESLWDTIT TSNYILARSV VPDLKEKELV 350
STEAQIQKMS QDLQLEALTI QSETQFLAGI NSQAANDCFK TLIAAMLSQR 400
TMSLDFVTTN YMSLISGMWL LTVIPNDMFL RESLVACELA IINTIVYPAF 450
GMQRMHYRNG DPQTPFQIAE QQIQNFQVAN WLHFTNNNRF RQVVIDGVLN 500
QTLNDNIRNG QVINQLMEAL MQLSRQQFPT MPVDYKRSIQ RGILLLSNRL 550
GQLVDLTRLV SYNYETLMAC VTMNMQHVQT LTTEKLQLTS VTSLCMLIGN 600
TTVIPSPQTL FHYYNVNVNF HSNYNERIND AVAIITAANR LNLYQKKMKS 650
IVEDFLKRLQ IFDVPRVPDD QMYRLRDRLR LLPVERRRLD IFNLILMNME 700
QIERASDKIA QGVIIAYRDM QLERDEMYGY VNIARNLDGY QQINLEELMR 750
TGDYGQITNM LLNNQPVALV GALPFVTDSS VISLIAKLDA TVFAQIVKLR 800
KVDTLKPILY KINSDSNDFY LVANYDWIPT STTKVYKQVP QPFDFRASMH 850
MLTSNLTFTV YSDLLSFVSA DTVEPINAVA FDNMRIMNEL 890
Length:890
Mass (Da):103,725
Last modified:April 29, 2008 - v1
Checksum:i456D9DD7605F6CDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF583022 Genomic RNA. Translation: ABU87831.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF583022 Genomic RNA. Translation: ABU87831.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
    Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
    J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTAD
AccessioniPrimary (citable) accession number: B1NKR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 16, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi