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B1NKR0

- VP2_ROTH7

UniProt

B1NKR0 - VP2_ROTH7

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (isolate Human/United Kingdom/A64/1987 G10-P11[14]-I2-R2-C2-M1-A3-N2-T6-E2-H3) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus A (isolate Human/United Kingdom/A64/1987 G10-P11[14]-I2-R2-C2-M1-A3-N2-T6-E2-H3) (RV-A)
    Taxonomic identifieri578827 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000001456: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 880880Inner capsid protein VP2PRO_0000368050Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9292Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni394 – 41421HydrophobicBy similarityAdd
    BLAST
    Regioni422 – 44221HydrophobicBy similarityAdd
    BLAST
    Regioni536 – 55722Leucine-zipper 1Sequence AnalysisAdd
    BLAST
    Regioni665 – 68622Leucine-zipper 2Sequence AnalysisAdd
    BLAST

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    B1NKR0-1 [UniParc]FASTAAdd to Basket

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    MAYRKRGARR EANVNNNDRM QEKDDEKQDQ NSKMQLSDKV LSKKEEVITD    50
    NQEEVKIADE VKKSTKEESK QLLEVLKTKE EHQKEIQYEI LQKTIPTFEP 100
    KESILKKLED IKPEQAKKQT KLFRIFEPRQ LPIYRANGEK ELRNRWYWKL 150
    KKDTLPDGDY DVREYFLNLY DQVLTEMPDY LLLKDMAVEN KNSRDAGKVV 200
    DSETASICDA IFQDEETEGA VRRFIAEMRQ RVQADRNVVN YPSILHPIDY 250
    AFNEYFLQHQ LVEPLNNDII FNYIPERIRN DVNYILNMDR NLPSTARYIR 300
    PNLLQDRLNL HDNFESLWDT ITTSNYILAR SVVPDLKELV STEAQIQKMS 350
    QDLQLEALTI QSETQFLTGI NSQAANDCFK TLIAAMLSQR TMSLDFVTTN 400
    YMSLISGMWL LTVVPNDMFI RESLVACQLA IVNTIVYPAF GMQRMHYRNG 450
    DPQTPFQIAE QQIQNFQVAN WLHFVNNNQF RQVVIDGVLN QVLNDNIRNG 500
    HVINQLMEAL MQLSRQQFPT MPVDYKRSIQ RGILLLSNRL GQLVDLTRLL 550
    AYNYETLMAC ITMNMQHVQT LTTEKLQLTS VTSLCMLIGN ATVIPSPQTL 600
    FHYYNVNVNF HSNYNERIND AVAIITAANR LNLYQKKMKS IVEDFLKRLH 650
    IFDVARVPDD QMYRLRDRLR LLPVEVRRLD IFNLILMNMD QIERASDKIA 700
    QGVIIAYRDM QLERDEMYGY VNIARNLDGF QQINLEELMR TGDYAQITNM 750
    LLNNQPVALV GALPFITDSS VISLIAKLDA TVFAQIVKLR KVDTLKPILY 800
    KINSDSNDFY LVANYDWVPT STTKVYKQVP QQFDFRNSMH MLTSNLTFTV 850
    YSDLLAFVSA DTVEPINAVA FDNMRIMNEL 880
    Length:880
    Mass (Da):102,471
    Last modified:April 29, 2008 - v1
    Checksum:i86100F0AFE81E911
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF583018 Genomic RNA. Translation: ABU87827.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF583018 Genomic RNA. Translation: ABU87827.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
      Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
      J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTH7
    AccessioniPrimary (citable) accession number: B1NKR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3