ID   B1N0C6_LEUCK            Unreviewed;       692 AA.
AC   B1N0C6;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Topoisomerase IA {ECO:0000313|EMBL:ACA83228.1};
DE            EC=5.99.1.2 {ECO:0000313|EMBL:ACA83228.1};
GN   OrderedLocusNames=LCK_01404 {ECO:0000313|EMBL:ACA83228.1};
OS   Leuconostoc citreum (strain KM20).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Leuconostoc.
OX   NCBI_TaxID=349519 {ECO:0000313|EMBL:ACA83228.1, ECO:0000313|Proteomes:UP000002166};
RN   [1] {ECO:0000313|EMBL:ACA83228.1, ECO:0000313|Proteomes:UP000002166}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KM20 {ECO:0000313|EMBL:ACA83228.1,
RC   ECO:0000313|Proteomes:UP000002166};
RX   PubMed=18281406; DOI=10.1128/JB.01862-07;
RA   Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S.,
RA   Lee S., Park H.-S., Park Y.-H., Oh T.K.;
RT   "Complete genome sequence of Leuconostoc citreum KM20.";
RL   J. Bacteriol. 190:3093-3094(2008).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ489736; ACA83228.1; -; Genomic_DNA.
DR   RefSeq; WP_004906674.1; NC_010471.1.
DR   AlphaFoldDB; B1N0C6; -.
DR   STRING; 349519.LCK_01404; -.
DR   KEGG; lci:LCK_01404; -.
DR   eggNOG; COG0550; Bacteria.
DR   HOGENOM; CLU_372475_0_0_9; -.
DR   OrthoDB; 9803554at2; -.
DR   Proteomes; UP000002166; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd01028; TOPRIM_TopoIA; 1.
DR   Gene3D; 3.40.50.140; -; 1.
DR   Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR   Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR   Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR013826; Topo_IA_cen_sub3.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR   PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   PRINTS; PR00417; PRTPISMRASEI.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ACA83228.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          3..151
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
SQ   SEQUENCE   692 AA;  77907 MW;  F9AE643BC5206633 CRC64;
     MPNYLILTEK PSAAANFVKA LGGKNGQFDT FTYTITNLRG HVMTLKDPEE MVSEDLKKQY
     KSWLIKHLPW NLNDFNWART YIRQRNLRTG KVASTKQLVD DLKKEAANGY DAIVIATDTD
     PSGEGELLAW EALEAIKWRG QVLRANFMDE SVKGIQTSMQ HLRDVSDKNQ DGEYIKGESR
     NRWDFASMQL TRIATTAAKK QGFKVVAREG RLKSVIVWQI YAQLEAIKRY VKKPYFEVKF
     KDLAGHIFGR ITPEGDVIPW RFDSKAVAQQ DLLQYHESAV TNERYQTRTQ APGKLLDLAG
     LAAILAPRGF SAKEVLSTYQ KMYEAQVVSY PRTEDKTVTP EQFNELLPKI DQIAQVVHVD
     TALLTHRQPR ATHVKNQGAH GANRPGENVP TDLATLTKFG ASAQAIYEVL AKNYLAMLAE
     DYVYDHVTAN LTDYPIFKTA YNVPVQLNFK AVYDSQRAIK VDDDDETAVM GQLGPTAQPY
     LYEGANKKPQ APSTKWIMAF LEKHNVGTGA TRVSTLSDMS RGTKAMIKET RGKLTLTETG
     NVSAVMVKGT WIASPKITKR LFEMMDQVGR FEMTMPKLLD SVTQVVVHDM PIMVANAEQL
     ETLLGQPKIK PKRPVSEKTT GQFKGEEITF AKEWSGHVFT DEELTKLLNG AEISFEAKSK
     RGKLYTATGT MAKQTYKGRT FYGFKLKPKP KK
//