B1N009 (HIS8_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	LCK_01287

Organism

Leuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]

Taxonomic identifier

349519 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000135406
Amino acid modifications
	Modified residue	222	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1N009 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 1FB7738380AA19F8	FASTA	354	39,476
	10 20 30 40 50 60 MKETIKNMAA YEAELPVAEV KATYGVSHVA RLSANESPYG PSPKVGPAIR DVSDDVLGFY 70 80 90 100 110 120 PDGQATALRQ AVAKLEQVNP DSLVFGAGAD ELIELLTRVI LTPNDNVIVP NPTFGEYAMH 130 140 150 160 170 180 AQIEQATTKS IPVNQDTGHV DFDAMFDAVD EHTTMVWLAN PNNPTGVFET RSDILSFLQK 190 200 210 220 230 240 LPQSVVLVVD EAYYDFVDQI DATVIRDVKD YPNLVVLRTL SKAYGLANLR IGYGVMQEPL 250 260 270 280 290 300 YQVMQAVRLP YNLNTYQITG AVAALSDQLY LQSVVAKVKS EREKFEQFLT KHQFKYYQSQ 310 320 330 340 350 TNFLWIKVGD AKRVGEALLS EGYQINDRLN AEWIRIALGT VSDNEGMQRI LLNF

References

[1]

"Complete genome sequence of Leuconostoc citreum KM20." Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K. J. Bacteriol. 190:3093-3094(2008) [PubMed: 18281406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KM20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ489736 Genomic DNA. Translation: ACA83111.1.
RefSeq	YP_001728555.1. NC_010471.1.
3D structure databases
ProteinModelPortal	B1N009.
ModBase	Search...
Protein-protein interaction databases
STRING	B1N009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6062648.
GenomeReviews	Gene locus LCK_01287 in contig DQ489736_GR.
KEGG	lci:LCK_01287.
PATRIC	32615880. VBILeuCit37309_1416.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646350.
OMA	ECLDASE.
ProtClustDB	CLSK2319081.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_LEUCK

Accession

Primary (citable) accession number: B1N009

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program