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B1MZP8 (NADK_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:LCK_01173
OrganismLeuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]
Taxonomic identifier349519 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265NAD kinase HAMAP-Rule MF_00361
PRO_1000120871

Regions

Nucleotide binding45 – 462NAD By similarity
Nucleotide binding121 – 1222NAD By similarity

Sites

Active site451Proton acceptor By similarity
Binding site1471NAD By similarity
Binding site1491NAD By similarity
Binding site1841NAD; via carbonyl oxygen By similarity
Binding site2211NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B1MZP8 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 77A5B268857DC356

FASTA26529,451
        10         20         30         40         50         60 
MKIAIFNNDA KNSQMITQSL VASLEKNGLT IDNQHPDIVI TVGGDGTLLG AFQHYVDQID 

        70         80         90        100        110        120 
TIRFVGLHTG HLGFYTDWLS TELANLVSSL THDNGQRVSY PLLDMTVVHE SGEQYHFLAL 

       130        140        150        160        170        180 
NEAAIKQPVG TLVADIYLGG QLFERFRGDG IAVATPTGST AYNKANGGAV LHPKLSAIQM 

       190        200        210        220        230        240 
SEIASINNRV FRTLGSPLVV PKGEEIIVKP KSNHFLVMYD QSEIKGRHIN ELRFRVADKQ 

       250        260 
VHFAAYRHVD FWQRVHRAFI NDIES 

« Hide

References

[1]"Complete genome sequence of Leuconostoc citreum KM20."
Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K.
J. Bacteriol. 190:3093-3094(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KM20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ489736 Genomic DNA. Translation: ACA83000.1.
RefSeqYP_001728444.1. NC_010471.1.

3D structure databases

ProteinModelPortalB1MZP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349519.LCK_01173.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA83000; ACA83000; LCK_01173.
GeneID6064207.
KEGGlci:LCK_01173.
PATRIC32615650. VBILeuCit37309_1301.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAIQMSEIA.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycLCIT349519:GHNF-1196-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_LEUCK
AccessionPrimary (citable) accession number: B1MZP8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families