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B1MZP4

- ASSY_LEUCK

UniProt

B1MZP4 - ASSY_LEUCK

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861CitrullineUniRule annotation
Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
Binding sitei118 – 1181AspartateUniRule annotation
Binding sitei122 – 1221AspartateUniRule annotation
Binding sitei122 – 1221CitrullineUniRule annotation
Binding sitei123 – 1231AspartateUniRule annotation
Binding sitei126 – 1261CitrullineUniRule annotation
Binding sitei174 – 1741CitrullineUniRule annotation
Binding sitei259 – 2591CitrullineUniRule annotation
Binding sitei271 – 2711CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCIT349519:GHNF-1192-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:LCK_01169
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000002166: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Argininosuccinate synthasePRO_1000089043Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349519.LCK_01169.

Structurei

3D structure databases

ProteinModelPortaliB1MZP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiDIAHENE.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MZP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEKLVLAYS GGLDTSVAIP WLKEKGYDVI AVVLNVGQHG KDMVAIQEKA
60 70 80 90 100
LKVGASQSIV IDAQAEFADQ YVAPVIKANM LYEGEYPMVS ALSRPLIIKK
110 120 130 140 150
LVDIAHENEA VAIAHGSTGH GNDQVRFEAA IHALDPDMKI EAPIRDFQWS
160 170 180 190 200
REEEIEYAQQ HDVPVPINLE SPYSIDENLW GRANEAGILE NPWHQAPEDA
210 220 230 240 250
YALTTAIENT PDIPEFVDVT FTAGIPTALD GNEMPLADLI IKLNIMAGTH
260 270 280 290 300
GIGRIDHIEN RLVGIKSREI YEAPAAAVLM TAHKDLEDLT LERDVAHFKP
310 320 330 340 350
MVEQQLANLV YEAKWVSPLF DSLMAFVDET QKNVNGVVKM KLFKGSAIAV
360 370 380 390 400
ARQSEHNSLY DEDLATYTSA SSFDQAAAVG FIKLWTLSNT VYEQVNHVHS
410
QKPSQLKLKN
Length:410
Mass (Da):45,291
Last modified:April 29, 2008 - v1
Checksum:iBE7A58585F222813
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82996.1.
RefSeqiYP_001728440.1. NC_010471.1.

Genome annotation databases

EnsemblBacteriaiACA82996; ACA82996; LCK_01169.
GeneIDi6064202.
KEGGilci:LCK_01169.
PATRICi32615642. VBILeuCit37309_1297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82996.1 .
RefSeqi YP_001728440.1. NC_010471.1.

3D structure databases

ProteinModelPortali B1MZP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349519.LCK_01169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA82996 ; ACA82996 ; LCK_01169 .
GeneIDi 6064202.
KEGGi lci:LCK_01169.
PATRICi 32615642. VBILeuCit37309_1297.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi DIAHENE.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci LCIT349519:GHNF-1192-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KM20.

Entry informationi

Entry nameiASSY_LEUCK
AccessioniPrimary (citable) accession number: B1MZP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3