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B1MZE7

- TRMB_LEUCK

UniProt

B1MZE7 - TRMB_LEUCK

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, LCK_01072
Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461S-adenosyl-L-methionine By similarity
Binding sitei71 – 711S-adenosyl-L-methionine By similarity
Binding sitei100 – 1001S-adenosyl-L-methionine By similarity
Active sitei122 – 1221 By similarity
Binding sitei122 – 1221S-adenosyl-L-methionine By similarity
Binding sitei126 – 1261Substrate By similarity
Binding sitei158 – 1581Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLCIT349519:GHNF-1094-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:LCK_01072
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000002166: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_1000136354Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349519.LCK_01072.

Structurei

3D structure databases

ProteinModelPortaliB1MZE7.
SMRiB1MZE7. Positions 9-219.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MZE7-1 [UniParc]FASTAAdd to Basket

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MHLRAKPWAT DWLAAHSDIV ITQGRATEQI GQWQKLFAKA QPIHVEIGSG    50
KGQFILGMAL AHPEINYIGM EIQETAVAIA ARKSFDQVGE LPNLRYIYGN 100
GNGVETYFEK AEVEKIYLNF SDPWPKTRHE SRRLTYKTFL QSYEAVLPEH 150
GEVEFKTDNR HLFEYSIVSF MNYGMRWATT DFTLDLHADA EKVIGNVETE 200
YEQKFMAKGQ PIYKIKAHF 219
Length:219
Mass (Da):25,236
Last modified:April 29, 2008 - v1
Checksum:i41292505021702BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82899.1.
RefSeqiYP_001728343.1. NC_010471.1.

Genome annotation databases

EnsemblBacteriaiACA82899; ACA82899; LCK_01072.
GeneIDi6064036.
KEGGilci:LCK_01072.
PATRICi32615440. VBILeuCit37309_1197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82899.1 .
RefSeqi YP_001728343.1. NC_010471.1.

3D structure databases

ProteinModelPortali B1MZE7.
SMRi B1MZE7. Positions 9-219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349519.LCK_01072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA82899 ; ACA82899 ; LCK_01072 .
GeneIDi 6064036.
KEGGi lci:LCK_01072.
PATRICi 32615440. VBILeuCit37309_1197.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci LCIT349519:GHNF-1094-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KM20.

Entry informationi

Entry nameiTRMB_LEUCK
AccessioniPrimary (citable) accession number: B1MZE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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