B1MZ77 (PYRB_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	LCK_01002

Organism

Leuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]

Taxonomic identifier

349519 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000088776

Sequences

	Sequence		Length	Mass (Da)
	B1MZ77 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 0657AEB905EA7EE3	FASTA	303	34,281
	10 20 30 40 50 60 MRHFLNINAI ELDDVVDLVH RALAIKAGRS VIQSNLTVTN LFFENSTRTH SSFQMAENRL 70 80 90 100 110 120 GYQQIDIDPQ QSSMSKGESL TDTLKTLKAI GVDVAVIRHT VNNWYDQVLT ATGHEIPHLI 130 140 150 160 170 180 NAGDGSGQHP SQSLLDLVTI YEQFNHFAGL NIRIVGDLAH SRVARSNAEI LHHLGANMTF 190 200 210 220 230 240 SGPKDWQPND FGKFGQFVAI DDDWENLDVV IFLRVQHERI TQTENQNFST KQYHEQFGLN 250 260 270 280 290 300 RVRYERLKAA AIIMHPAPVN RDVEIADELV EAPKSRIFEQ MNNGVYARMA ILEYTTEATH ATH

References

[1]

"Complete genome sequence of Leuconostoc citreum KM20." Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K. J. Bacteriol. 190:3093-3094(2008) [PubMed: 18281406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KM20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ489736 Genomic DNA. Translation: ACA82829.1.
RefSeq	YP_001728273.1. NC_010471.1.
3D structure databases
ProteinModelPortal	B1MZ77.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MZ77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6063744.
GenomeReviews	Gene locus LCK_01002 in contig DQ489736_GR.
KEGG	lci:LCK_01002.
PATRIC	32615294. VBILeuCit37309_1127.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	VGIPIIN.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_LEUCK

Accession

Primary (citable) accession number: B1MZ77

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program