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B1MZ05 (B1MZ05_LEUCK) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL ACA82757.1
Ordered Locus Names:LCK_00929
OrganismLeuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]
Taxonomic identifier349519 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding74 – 763NADP By similarity PIRSR PIRSR000109-3
Region128 – 1303Substrate binding By similarity PIRSR PIRSR000109-2
Region187 – 1882Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1841Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1911Proton donor By similarity PIRSR PIRSR000109-1
Binding site1021NADP By similarity PIRSR PIRSR000109-3
Binding site1021Substrate By similarity PIRSR PIRSR000109-2
Binding site1921Substrate By similarity PIRSR PIRSR000109-2
Binding site2631Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2901Substrate By similarity PIRSR PIRSR000109-2
Binding site4481Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B1MZ05 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 51A9A5A816E57359

FASTA47552,327
        10         20         30         40         50         60 
MVEADFGVVG LAVMGRNLAL NVESRGYRVA VYNRSRERTD DLVKKHADKK FVPSYTVASF 

        70         80         90        100        110        120 
VKAIKAPRRI LLMVKAGKGT YAVINELLPH LEKGDTLIDG GNTFFEDTIR RSDTLAASGI 

       130        140        150        160        170        180 
NFIGMGVSGG ELGALQGPSL MPGGQRDAYD LVEPILKQIA AKAPEDGVPT VTYVGPNGAG 

       190        200        210        220        230        240 
HYVKMVHNGI EYGDMQLIAE SYDILKRVLK LDQQQLATTF SEWNTGELDS YLVEITADIL 

       250        260        270        280        290        300 
TRKDDQGSDK PIVDMILDRA GNKGTGKWSS QSALEVGAPQ SLITESVYAR YISAMKADRV 

       310        320        330        340        350        360 
AASEVLSGPE FSFTGDEKAA IEDVRKALYF GKIMSYAQGF DQLRMASEHY DWHLPFGELA 

       370        380        390        400        410        420 
QLWRAGAIIR AQFLQRITDA FTKNTGLHNL LLDPYFKDIA QDYQAATRRV VALAVQAGIP 

       430        440        450        460        470 
TPSLSAAIAY YDSYRSAVLP ANLIQAQRDY FGAHTYERTD KPAGEMYHYG WYDEA

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References

[1]"Complete genome sequence of Leuconostoc citreum KM20."
Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K.
J. Bacteriol. 190:3093-3094(2008) [PubMed: 18281406] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ489736 Genomic DNA. Translation: ACA82757.1.
RefSeqYP_001728201.1. NC_010471.1.

3D structure databases

ProteinModelPortalB1MZ05.
SMRB1MZ05. Positions 3-472.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MZ05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6063197.
GenomeReviewsGene locus LCK_00929 in contig DQ489736_GR.
KEGGlci:LCK_00929.
PATRIC32615150. VBILeuCit37309_1055.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBCLSK2318919.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1MZ05_LEUCK
AccessionPrimary (citable) accession number: B1MZ05
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info