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B1MY45

- FTHS_LEUCK

UniProt

B1MY45 - FTHS_LEUCK

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCIT349519:GHNF-638-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LCK_00614
    OrganismiLeuconostoc citreum (strain KM20)
    Taxonomic identifieri349519 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
    ProteomesiUP000002166: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_1000196813Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349519.LCK_00614.

    Structurei

    3D structure databases

    ProteinModelPortaliB1MY45.
    SMRiB1MY45. Positions 4-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1MY45-1 [UniParc]FASTAAdd to Basket

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    MQTDIAIAQS AEILPITQIA EKAGLKPNEI LPYGYDKAKI KLDPTISRKK    50
    DLGKLILVTS INPTPAGEGK STVTVGLADA LALAGKKTMI ALREPSLGPV 100
    MGMKGGATGG GMSQVIPMAD INLHFTGDFH ALTAAHDTLA AVVDNSLQQG 150
    NPLNIDPRRI IWKRVLDIND RALRHITIGM GGPTSGVPRE DGFDITVASE 200
    LMAILTLSTD LMDLKARVAR IVVGYTYDKV PVTVADLGVS GALAVLLKDA 250
    IMPNLVQTLA HTPAIIHGGP FANIAQGTNS ILATKTALQL ADYTVTEGGF 300
    GADLGGEKFL DVKVPILGKT PDTIVVVATV RALKHHGGVA LADLNNENLT 350
    ALAAGLENLG QHLKAMGRYG VPVVVAINRF SADTDSEIQA IKDYAQAFGA 400
    AAYTTTVWAE GGAGAQDLAA AVIEAADQEA DYTPLYQPEN EAIDKLNAIV 450
    TTIYGGLGVE LSATAQKQLM AFKAQGWDKL PIIMAKTQYS FSDDPKRLGA 500
    PKDFVIHVRE FVPKLGAGFL VAMTGSILTM PGLPKHPAAL DIDIDETGKI 550
    TGLF 554
    Length:554
    Mass (Da):58,270
    Last modified:April 29, 2008 - v1
    Checksum:i20590D1B6E15559C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ489736 Genomic DNA. Translation: ACA82447.1.
    RefSeqiYP_001727891.1. NC_010471.1.

    Genome annotation databases

    EnsemblBacteriaiACA82447; ACA82447; LCK_00614.
    GeneIDi6063834.
    KEGGilci:LCK_00614.
    PATRICi32614513. VBILeuCit37309_0738.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ489736 Genomic DNA. Translation: ACA82447.1 .
    RefSeqi YP_001727891.1. NC_010471.1.

    3D structure databases

    ProteinModelPortali B1MY45.
    SMRi B1MY45. Positions 4-552.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349519.LCK_00614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA82447 ; ACA82447 ; LCK_00614 .
    GeneIDi 6063834.
    KEGGi lci:LCK_00614.
    PATRICi 32614513. VBILeuCit37309_0738.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LCIT349519:GHNF-638-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KM20.

    Entry informationi

    Entry nameiFTHS_LEUCK
    AccessioniPrimary (citable) accession number: B1MY45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3