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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCIT349519:GHNF-638-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LCK_00614
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000002166: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Formate--tetrahydrofolate ligasePRO_1000196813Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349519.LCK_00614.

Structurei

3D structure databases

ProteinModelPortaliB1MY45.
SMRiB1MY45. Positions 4-552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MY45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTDIAIAQS AEILPITQIA EKAGLKPNEI LPYGYDKAKI KLDPTISRKK
60 70 80 90 100
DLGKLILVTS INPTPAGEGK STVTVGLADA LALAGKKTMI ALREPSLGPV
110 120 130 140 150
MGMKGGATGG GMSQVIPMAD INLHFTGDFH ALTAAHDTLA AVVDNSLQQG
160 170 180 190 200
NPLNIDPRRI IWKRVLDIND RALRHITIGM GGPTSGVPRE DGFDITVASE
210 220 230 240 250
LMAILTLSTD LMDLKARVAR IVVGYTYDKV PVTVADLGVS GALAVLLKDA
260 270 280 290 300
IMPNLVQTLA HTPAIIHGGP FANIAQGTNS ILATKTALQL ADYTVTEGGF
310 320 330 340 350
GADLGGEKFL DVKVPILGKT PDTIVVVATV RALKHHGGVA LADLNNENLT
360 370 380 390 400
ALAAGLENLG QHLKAMGRYG VPVVVAINRF SADTDSEIQA IKDYAQAFGA
410 420 430 440 450
AAYTTTVWAE GGAGAQDLAA AVIEAADQEA DYTPLYQPEN EAIDKLNAIV
460 470 480 490 500
TTIYGGLGVE LSATAQKQLM AFKAQGWDKL PIIMAKTQYS FSDDPKRLGA
510 520 530 540 550
PKDFVIHVRE FVPKLGAGFL VAMTGSILTM PGLPKHPAAL DIDIDETGKI

TGLF
Length:554
Mass (Da):58,270
Last modified:April 29, 2008 - v1
Checksum:i20590D1B6E15559C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ489736 Genomic DNA. Translation: ACA82447.1.
RefSeqiYP_001727891.1. NC_010471.1.

Genome annotation databases

EnsemblBacteriaiACA82447; ACA82447; LCK_00614.
GeneIDi6063834.
KEGGilci:LCK_00614.
PATRICi32614513. VBILeuCit37309_0738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ489736 Genomic DNA. Translation: ACA82447.1.
RefSeqiYP_001727891.1. NC_010471.1.

3D structure databases

ProteinModelPortaliB1MY45.
SMRiB1MY45. Positions 4-552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349519.LCK_00614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA82447; ACA82447; LCK_00614.
GeneIDi6063834.
KEGGilci:LCK_00614.
PATRICi32614513. VBILeuCit37309_0738.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciLCIT349519:GHNF-638-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KM20.

Entry informationi

Entry nameiFTHS_LEUCK
AccessioniPrimary (citable) accession number: B1MY45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.