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B1MY45 (FTHS_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LCK_00614
OrganismLeuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]
Taxonomic identifier349519 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000196813

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B1MY45 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 20590D1B6E15559C

FASTA55458,270
        10         20         30         40         50         60 
MQTDIAIAQS AEILPITQIA EKAGLKPNEI LPYGYDKAKI KLDPTISRKK DLGKLILVTS 

        70         80         90        100        110        120 
INPTPAGEGK STVTVGLADA LALAGKKTMI ALREPSLGPV MGMKGGATGG GMSQVIPMAD 

       130        140        150        160        170        180 
INLHFTGDFH ALTAAHDTLA AVVDNSLQQG NPLNIDPRRI IWKRVLDIND RALRHITIGM 

       190        200        210        220        230        240 
GGPTSGVPRE DGFDITVASE LMAILTLSTD LMDLKARVAR IVVGYTYDKV PVTVADLGVS 

       250        260        270        280        290        300 
GALAVLLKDA IMPNLVQTLA HTPAIIHGGP FANIAQGTNS ILATKTALQL ADYTVTEGGF 

       310        320        330        340        350        360 
GADLGGEKFL DVKVPILGKT PDTIVVVATV RALKHHGGVA LADLNNENLT ALAAGLENLG 

       370        380        390        400        410        420 
QHLKAMGRYG VPVVVAINRF SADTDSEIQA IKDYAQAFGA AAYTTTVWAE GGAGAQDLAA 

       430        440        450        460        470        480 
AVIEAADQEA DYTPLYQPEN EAIDKLNAIV TTIYGGLGVE LSATAQKQLM AFKAQGWDKL 

       490        500        510        520        530        540 
PIIMAKTQYS FSDDPKRLGA PKDFVIHVRE FVPKLGAGFL VAMTGSILTM PGLPKHPAAL 

       550 
DIDIDETGKI TGLF 

« Hide

References

[1]"Complete genome sequence of Leuconostoc citreum KM20."
Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K.
J. Bacteriol. 190:3093-3094(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KM20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ489736 Genomic DNA. Translation: ACA82447.1.
RefSeqYP_001727891.1. NC_010471.1.

3D structure databases

ProteinModelPortalB1MY45.
SMRB1MY45. Positions 4-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349519.LCK_00614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA82447; ACA82447; LCK_00614.
GeneID6063834.
KEGGlci:LCK_00614.
PATRIC32614513. VBILeuCit37309_0738.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycLCIT349519:GHNF-638-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LEUCK
AccessionPrimary (citable) accession number: B1MY45
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways