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B1MY42 (PUR9_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:LCK_00611
OrganismLeuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]
Taxonomic identifier349519 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000096072

Sequences

Sequence LengthMass (Da)Tools
B1MY42 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 8764CDD9E6066086

FASTA50855,006
        10         20         30         40         50         60 
MTRALLSVSD KTGLVPFAEK LVALGYELVS TGGTHRVLAA AGLDVIAIDD VTDFPEMLDG 

        70         80         90        100        110        120 
RVKTLHPRVH AGLLARRDLP EHMAKMAEFD ITPIDMVVVN LYPFKSTIQK DGVTEAEAIE 

       130        140        150        160        170        180 
NIDIGGPSML RSAAKNFAGV LPIVDPADYD VVVDKLQSGS IDADYRKSLA AKVFQHTAAY 

       190        200        210        220        230        240 
DALIADYLTV AEFPNNLTLP YEKFDDMRYG ENPHQKAAAY KTALPEDYSV LNANILHGKQ 

       250        260        270        280        290        300 
LSYNNIRDAD AALRIIAEFE ETTVVTVKHM NPAGIGQGST IETAWDKAFA ADDVSIFGGI 

       310        320        330        340        350        360 
VALNREVDAA TAEKMHAIFL EIIIAPSFTP EAFDILSAKK NLRLLTVPFT TTVPQKLEVT 

       370        380        390        400        410        420 
SVLGGVVVQE RDLYTESKAN FEVVSKVQPT EAQLRAMIFA QKVVKHVKSN AIIVARDGQT 

       430        440        450        460        470        480 
LGMGAGQPNR IDSVVYAIQK AAVKSGFDEA VLASDAFFPM DDSVQYAAEN GIRAVVEPGG 

       490        500 
SIKDKDSIAK ADELGIALVF SGTRHFKH 

« Hide

References

[1]"Complete genome sequence of Leuconostoc citreum KM20."
Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K.
J. Bacteriol. 190:3093-3094(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KM20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ489736 Genomic DNA. Translation: ACA82444.1.
RefSeqYP_001727888.1. NC_010471.1.

3D structure databases

ProteinModelPortalB1MY42.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349519.LCK_00611.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA82444; ACA82444; LCK_00611.
GeneID6063820.
KEGGlci:LCK_00611.
PATRIC32614507. VBILeuCit37309_0735.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMAGIGQADN.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycLCIT349519:GHNF-635-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_LEUCK
AccessionPrimary (citable) accession number: B1MY42
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways