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B1MY42

- PUR9_LEUCK

UniProt

B1MY42 - PUR9_LEUCK

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, LCK_00611
Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLCIT349519:GHNF-635-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:LCK_00611
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000002166: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000096072Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349519.LCK_00611.

Structurei

3D structure databases

ProteinModelPortaliB1MY42.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B1MY42-1 [UniParc]FASTAAdd to Basket

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MTRALLSVSD KTGLVPFAEK LVALGYELVS TGGTHRVLAA AGLDVIAIDD    50
VTDFPEMLDG RVKTLHPRVH AGLLARRDLP EHMAKMAEFD ITPIDMVVVN 100
LYPFKSTIQK DGVTEAEAIE NIDIGGPSML RSAAKNFAGV LPIVDPADYD 150
VVVDKLQSGS IDADYRKSLA AKVFQHTAAY DALIADYLTV AEFPNNLTLP 200
YEKFDDMRYG ENPHQKAAAY KTALPEDYSV LNANILHGKQ LSYNNIRDAD 250
AALRIIAEFE ETTVVTVKHM NPAGIGQGST IETAWDKAFA ADDVSIFGGI 300
VALNREVDAA TAEKMHAIFL EIIIAPSFTP EAFDILSAKK NLRLLTVPFT 350
TTVPQKLEVT SVLGGVVVQE RDLYTESKAN FEVVSKVQPT EAQLRAMIFA 400
QKVVKHVKSN AIIVARDGQT LGMGAGQPNR IDSVVYAIQK AAVKSGFDEA 450
VLASDAFFPM DDSVQYAAEN GIRAVVEPGG SIKDKDSIAK ADELGIALVF 500
SGTRHFKH 508
Length:508
Mass (Da):55,006
Last modified:April 29, 2008 - v1
Checksum:i8764CDD9E6066086
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82444.1.
RefSeqiYP_001727888.1. NC_010471.1.

Genome annotation databases

EnsemblBacteriaiACA82444; ACA82444; LCK_00611.
GeneIDi6063820.
KEGGilci:LCK_00611.
PATRICi32614507. VBILeuCit37309_0735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82444.1 .
RefSeqi YP_001727888.1. NC_010471.1.

3D structure databases

ProteinModelPortali B1MY42.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349519.LCK_00611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA82444 ; ACA82444 ; LCK_00611 .
GeneIDi 6063820.
KEGGi lci:LCK_00611.
PATRICi 32614507. VBILeuCit37309_0735.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LCIT349519:GHNF-635-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KM20.

Entry informationi

Entry nameiPUR9_LEUCK
AccessioniPrimary (citable) accession number: B1MY42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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