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B1MY11

- SYL_LEUCK

UniProt

B1MY11 - SYL_LEUCK

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei578 – 5781ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCIT349519:GHNF-604-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LCK_00580
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000002166: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Leucine--tRNA ligasePRO_1000091334Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349519.LCK_00580.

Structurei

3D structure databases

ProteinModelPortaliB1MY11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi575 – 5795"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MY11 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYEHQQIEQ KWQKFWDDNQ TFATSDTTDK PKYYAVDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI MSRFKRAKGF NVLHPMGWDA FGLPAEQYAM KTGHNPADFT
110 120 130 140 150
SQNIDHFREQ IKSLGLSYDW NREINTTDPS YYKWTQWIFE KLYEKGLAYE
160 170 180 190 200
SNMMVNWDPI DRVVLANEEV IDGKSERSGN KVERKALRQW VLKITAYADR
210 220 230 240 250
LVDDLDDLDW PEAIKEQQRN WIGRSKGAAV FFNVDHADAK IEVYTTRPDT
260 270 280 290 300
LFGATYMVLA PEHELVDSIV TAEQKQAVAD YRAAIAAKSD LERTDLNKDK
310 320 330 340 350
TGVFTGAYGI NPINGEKLPI WIADYVLASY GTGAIMAVPA HDDRDFEFAK
360 370 380 390 400
KFDLAIKPVI AGGENDDVAY TGDGVHINSD FLDGLDKATA IDQAIDWLEA
410 420 430 440 450
HQAGHAQTNF RLRDWIFSRQ RYWGEPIPVI HWEDGTTSLV PENELPLLLP
460 470 480 490 500
HATELRPSGS GESPLANLTD WLEVTRDDGV KGRRETNTMP QWAGSSWYFL
510 520 530 540 550
RYIDPHNDHQ LADPEKLKYW MNVDLYVGGA EHAVLHLLYA RFWHKFLYDL
560 570 580 590 600
GVVPTKEPFQ KLVNQGMILG ANHEKMSKSK GNVVNPDDIV REYGADTLRV
610 620 630 640 650
YEMFMGPLTQ SKPWSEEGIT GSRRWLDRVW RLLIDDEGQL RDHVTTVNPG
660 670 680 690 700
DLDKIYHQTV KKVTDDLENM RFNTAISQMM VFVNDAYKSD ALPVTYMNGF
710 720 730 740 750
IQLLAPFAPH LAEELWVRLG NRESISYVSW PTYDDTKLVD DTVEIIFQVN
760 770 780 790 800
GKVRGKATVA RDINQDDMIT AAKADDNVQN FITGKTVRKV IAIPGKFVNI

VVS
Length:803
Mass (Da):91,586
Last modified:April 29, 2008 - v1
Checksum:i2E4AF1E47D8BE59C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82413.1.
RefSeqiYP_001727857.1. NC_010471.1.

Genome annotation databases

EnsemblBacteriaiACA82413; ACA82413; LCK_00580.
GeneIDi6063670.
KEGGilci:LCK_00580.
PATRICi32614445. VBILeuCit37309_0704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ489736 Genomic DNA. Translation: ACA82413.1 .
RefSeqi YP_001727857.1. NC_010471.1.

3D structure databases

ProteinModelPortali B1MY11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349519.LCK_00580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA82413 ; ACA82413 ; LCK_00580 .
GeneIDi 6063670.
KEGGi lci:LCK_00580.
PATRICi 32614445. VBILeuCit37309_0704.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LCIT349519:GHNF-604-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KM20.

Entry informationi

Entry nameiSYL_LEUCK
AccessioniPrimary (citable) accession number: B1MY11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3