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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei578ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LCK_00580
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
Proteomesi
  • UP000002166 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913341 – 803Leucine--tRNA ligaseAdd BLAST803

Interactioni

Protein-protein interaction databases

STRINGi349519.LCK_00580

Structurei

3D structure databases

ProteinModelPortaliB1MY11
SMRiB1MY11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi575 – 579"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1MY11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYEHQQIEQ KWQKFWDDNQ TFATSDTTDK PKYYAVDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI MSRFKRAKGF NVLHPMGWDA FGLPAEQYAM KTGHNPADFT
110 120 130 140 150
SQNIDHFREQ IKSLGLSYDW NREINTTDPS YYKWTQWIFE KLYEKGLAYE
160 170 180 190 200
SNMMVNWDPI DRVVLANEEV IDGKSERSGN KVERKALRQW VLKITAYADR
210 220 230 240 250
LVDDLDDLDW PEAIKEQQRN WIGRSKGAAV FFNVDHADAK IEVYTTRPDT
260 270 280 290 300
LFGATYMVLA PEHELVDSIV TAEQKQAVAD YRAAIAAKSD LERTDLNKDK
310 320 330 340 350
TGVFTGAYGI NPINGEKLPI WIADYVLASY GTGAIMAVPA HDDRDFEFAK
360 370 380 390 400
KFDLAIKPVI AGGENDDVAY TGDGVHINSD FLDGLDKATA IDQAIDWLEA
410 420 430 440 450
HQAGHAQTNF RLRDWIFSRQ RYWGEPIPVI HWEDGTTSLV PENELPLLLP
460 470 480 490 500
HATELRPSGS GESPLANLTD WLEVTRDDGV KGRRETNTMP QWAGSSWYFL
510 520 530 540 550
RYIDPHNDHQ LADPEKLKYW MNVDLYVGGA EHAVLHLLYA RFWHKFLYDL
560 570 580 590 600
GVVPTKEPFQ KLVNQGMILG ANHEKMSKSK GNVVNPDDIV REYGADTLRV
610 620 630 640 650
YEMFMGPLTQ SKPWSEEGIT GSRRWLDRVW RLLIDDEGQL RDHVTTVNPG
660 670 680 690 700
DLDKIYHQTV KKVTDDLENM RFNTAISQMM VFVNDAYKSD ALPVTYMNGF
710 720 730 740 750
IQLLAPFAPH LAEELWVRLG NRESISYVSW PTYDDTKLVD DTVEIIFQVN
760 770 780 790 800
GKVRGKATVA RDINQDDMIT AAKADDNVQN FITGKTVRKV IAIPGKFVNI

VVS
Length:803
Mass (Da):91,586
Last modified:April 29, 2008 - v1
Checksum:i2E4AF1E47D8BE59C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ489736 Genomic DNA Translation: ACA82413.1
RefSeqiWP_004908127.1, NC_010471.1

Genome annotation databases

EnsemblBacteriaiACA82413; ACA82413; LCK_00580
GeneIDi35826123
KEGGilci:LCK_00580

Similar proteinsi

Entry informationi

Entry nameiSYL_LEUCK
AccessioniPrimary (citable) accession number: B1MY11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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