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B1MX61

- THIM_LEUCK

UniProt

B1MX61 - THIM_LEUCK

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381Substrate; via amide nitrogenUniRule annotation
    Binding sitei113 – 1131ATPUniRule annotation
    Binding sitei158 – 1581ATPUniRule annotation
    Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCIT349519:GHNF-296-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:LCK_00280
    OrganismiLeuconostoc citreum (strain KM20)
    Taxonomic identifieri349519 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
    ProteomesiUP000002166: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Hydroxyethylthiazole kinasePRO_0000383880Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349519.LCK_00280.

    Structurei

    3D structure databases

    ProteinModelPortaliB1MX61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiTISESTY.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1MX61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLSTLNETT PLVFNYANYV TPQFVANAVN VIGGSPIMAR EVAEFSDLVA    50
    VSDAVVVNTG TWRRAELLET VKLIQIANQT QTVVVLDPVA VGIPSRSVPV 100
    QELLTNSKVD IIRGNAAEIA WFAGIDFASH GIDAVGSGNI EQIAQLAANK 150
    TGAIIAMSGP SDVISDGKTT RVLPVNVPLL ASNVGTGDAL SAIIGAFNGD 200
    EISLDNTVRA MAMMKLAGLT ASHQVTTPGY FANQVLDELY LLSESKLETF 250
    IAKEVKKYE 259
    Length:259
    Mass (Da):27,404
    Last modified:April 29, 2008 - v1
    Checksum:i9C6AA0BDA1DA1CB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ489736 Genomic DNA. Translation: ACA82113.1.
    RefSeqiYP_001727557.1. NC_010471.1.

    Genome annotation databases

    EnsemblBacteriaiACA82113; ACA82113; LCK_00280.
    GeneIDi6063080.
    KEGGilci:LCK_00280.
    PATRICi32613819. VBILeuCit37309_0399.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ489736 Genomic DNA. Translation: ACA82113.1 .
    RefSeqi YP_001727557.1. NC_010471.1.

    3D structure databases

    ProteinModelPortali B1MX61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349519.LCK_00280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA82113 ; ACA82113 ; LCK_00280 .
    GeneIDi 6063080.
    KEGGi lci:LCK_00280.
    PATRICi 32613819. VBILeuCit37309_0399.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi TISESTY.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci LCIT349519:GHNF-296-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KM20.

    Entry informationi

    Entry nameiTHIM_LEUCK
    AccessioniPrimary (citable) accession number: B1MX61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3