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B1MX11 (B1MX11_LEUCK) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 1 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 1 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 1 HAMAP MF_01815
Gene names
Name:fabH1 HAMAP MF_01815 EMBL ACA82063.1
Ordered Locus Names:LCK_00230
OrganismLeuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]
Taxonomic identifier349519 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region253 – 2575ACP-binding By similarity HAMAP MF_01815

Sites

Active site1131 By similarity HAMAP MF_01815
Active site2521 By similarity HAMAP MF_01815
Active site2821 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B1MX11 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 3380BABC36A10E55

FASTA32435,036
        10         20         30         40         50         60 
MPGSKILASA HYVPSDIVTN DDLAKIMDTS DAWIQSHTGI KTRHMSLKGE NTSDLATKAA 

        70         80         90        100        110        120 
QLALDKADLA AEDIDLIIVT TFTPDGLAPS TAALVQRNLN ANKAWAYDIM TACSGFIFGL 

       130        140        150        160        170        180 
STADKFLRSG VYQHALVISA EVNSKMMDFT DRTSTVFFGD GAGAVVLTAD MQGNGFLAGE 

       190        200        210        220        230        240 
DMHTIGNADV VHSGRIPPLQ ELSAENYPKT DAFVQMGRDV FNEVTTLIPQ HIRDFLSSKS 

       250        260        270        280        290        300 
LKPSDIDYFI PHQANLRLIE YIAKDLDEPL SKFSTNIIRN GNTSSAGIAI GFDELNQSVN 

       310        320 
LTGKRVLLTG FGAGFTYGSI LMQF

« Hide

References

[1]"Complete genome sequence of Leuconostoc citreum KM20."
Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K.
J. Bacteriol. 190:3093-3094(2008) [PubMed: 18281406] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ489736 Genomic DNA. Translation: ACA82063.1.
RefSeqYP_001727507.1. NC_010471.1.

3D structure databases

ProteinModelPortalB1MX11.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MX11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6062819.
GenomeReviewsGene locus LCK_00230 in contig DQ489736_GR.
KEGGlci:LCK_00230.
PATRIC32613715. VBILeuCit37309_0348.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMALASAHYV.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1MX11_LEUCK
AccessionPrimary (citable) accession number: B1MX11
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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