B1MX05 (ACPS_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS

Gene names

Name:	acpS
Ordered Locus Names:	LCK_00224

Organism

Leuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]

Taxonomic identifier

349519 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Leuconostoc

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101
Cofactor	Magnesium By similarity. HAMAP MF_00101
Subcellular location	Cytoplasm By similarity HAMAP MF_00101.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 135	135	Holo-[acyl-carrier-protein] synthase HAMAP MF_00101		PRO_1000093892
Sites
	Metal binding	8	1	Magnesium By similarity
	Metal binding	58	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1MX05 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: B1DD575AF112E4E2	FASTA	135	15,373
	10 20 30 40 50 60 MIIGIGNDTE AISRVGQIVA RQTKFMDSIL TPAEREQALE RKGKHFHEFV AGRFSAKEAF 70 80 90 100 110 120 SKATGYGIGE KVHWHDIEIL NEPNGRPIMQ VKNFRYKTYV AITHSGDFVN TVVIIERLTI 130 LERLSLKFFP KRGVL

References

[1]

"Complete genome sequence of Leuconostoc citreum KM20." Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K. J. Bacteriol. 190:3093-3094(2008) [PubMed: 18281406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KM20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ489736 Genomic DNA. Translation: ACA82057.1.
RefSeq	YP_001727501.1. NC_010471.1.
3D structure databases
ProteinModelPortal	B1MX05.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MX05.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6063063.
GenomeReviews	Gene locus LCK_00224 in contig DQ489736_GR.
KEGG	lci:LCK_00224.
PATRIC	32613703. VBILeuCit37309_0342.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734479.
OMA	IFPSITH.
ProtClustDB	PRK00070.
Family and domain databases
HAMAP	MF_00101. AcpS. [Tree]
InterPro	IPR008278. 4-PPantetheinyl_Trfase. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase. [Graphical view]
Gene3D	G3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KO	K00997.
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. AcpS. 1 hit. TIGR00556. Pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACPS_LEUCK

Accession

Primary (citable) accession number: B1MX05

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program