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B1MWZ3

- DDL_LEUCK

UniProt

B1MWZ3 - DDL_LEUCK

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi303 – 3031Magnesium or manganese 1UniRule annotation
    Metal bindingi316 – 3161Magnesium or manganese 1UniRule annotation
    Metal bindingi316 – 3161Magnesium or manganese 2UniRule annotation
    Metal bindingi318 – 3181Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi170 – 22556ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCIT349519:GHNF-217-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlUniRule annotation
    Ordered Locus Names:LCK_00212
    OrganismiLeuconostoc citreum (strain KM20)
    Taxonomic identifieri349519 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
    ProteomesiUP000002166: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377D-alanine--D-alanine ligasePRO_1000091192Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349519.LCK_00212.

    Structurei

    3D structure databases

    ProteinModelPortaliB1MWZ3.
    SMRiB1MWZ3. Positions 3-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini140 – 349210ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1181.
    HOGENOMiHOG000011593.
    KOiK01921.
    OMAiCANREEL.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1MWZ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKKYVALIF GGNSSEHDVS KRSAQNFYDA ILATGKYRIT VFAIAQNGYV    50
    LDPERSKRIL ALEDERPIVA DYMTTVDQQD PLSRINALRA AGDFDIFFPV 100
    VHGNLGEDGT LQGLFKLLNK PYVGAPLRGH AVSFDKVLTK ELLTVNNIRN 150
    TKYIVVDEKT AKTLTWAQVV KDLGDVVFVK AANQGSSVGV SRAKTADEFE 200
    AALTDSFQYD YKVLIEAAVK GPRELEVGVI GNEDPIVSEI GAHHVPNQGD 250
    GDAWYDYNNK FVDNSSVQFE IPANLPDAVT AEVKDMALKA YKVLDLRGEA 300
    RMDFLLDENN VPYLGEPNTL PGFTNMSLFK RLWDYSDIDN VELVDKLIDY 350
    GFAEFEKNAQ LSYEFVSLGE EKIGKFN 377
    Length:377
    Mass (Da):41,977
    Last modified:April 29, 2008 - v1
    Checksum:iB8F1510431CC35A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ489736 Genomic DNA. Translation: ACA82045.1.
    RefSeqiWP_004909228.1. NC_010471.1.
    YP_001727489.1. NC_010471.1.

    Genome annotation databases

    EnsemblBacteriaiACA82045; ACA82045; LCK_00212.
    GeneIDi6063608.
    KEGGilci:LCK_00212.
    PATRICi32613659. VBILeuCit37309_0330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ489736 Genomic DNA. Translation: ACA82045.1 .
    RefSeqi WP_004909228.1. NC_010471.1.
    YP_001727489.1. NC_010471.1.

    3D structure databases

    ProteinModelPortali B1MWZ3.
    SMRi B1MWZ3. Positions 3-362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349519.LCK_00212.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA82045 ; ACA82045 ; LCK_00212 .
    GeneIDi 6063608.
    KEGGi lci:LCK_00212.
    PATRICi 32613659. VBILeuCit37309_0330.

    Phylogenomic databases

    eggNOGi COG1181.
    HOGENOMi HOG000011593.
    KOi K01921.
    OMAi CANREEL.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci LCIT349519:GHNF-217-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KM20.

    Entry informationi

    Entry nameiDDL_LEUCK
    AccessioniPrimary (citable) accession number: B1MWZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3