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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei263ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:LCK_00160
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
Proteomesi
  • UP000002166 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900851 – 498Glutamate--tRNA ligaseAdd BLAST498

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349519.LCK_00160

Structurei

3D structure databases

ProteinModelPortaliB1MWU1
SMRiB1MWU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi260 – 264"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK09698
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1MWU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDIRVRYA PSPTGHLHIG NARTAIFNWL FARHYNGKFI IRIEDTDSAR
60 70 80 90 100
NIADGEKSQL ENLAWLGLDW DESPEKPGEY GPYRQSERNE QGIYQPFIDK
110 120 130 140 150
LLTEGLAYKS YKTSEQLASE REAQQAAKQA PHYVYEYEGL TREEREAKYA
160 170 180 190 200
EFEAKGLKPV VRFRVPEEKT YAWDDIVKGH IEIGAKEVGG DWVIQKADGM
210 220 230 240 250
PTYNFAVVVD DHMMKISHVL RGDDHVSNTP KQMMIFEALG WDIPQFGHMA
260 270 280 290 300
LIINGETGKK LSKRDENVLQ FVEQYKALGY QPQAMVNFIG LLGWSPKGED
310 320 330 340 350
EIFSLEEFKQ MFDETRLSKA NAKFDQKKLE WINNQWMRRD LEEIMPQLIQ
360 370 380 390 400
ELVTANLVSP ADATAKADWL AQVIKVAGVE GISYTREIVD LVRQPFFELG
410 420 430 440 450
DITDEMVAYL TSEEGRRVFD AWESAYIALP DDATAEDYLN AIRGIQNQLE
460 470 480 490
IKGRNLWNPI RIATTHEVQG PNLPEMLVVL DKATVLQTMA DVKSNYLN
Length:498
Mass (Da):57,008
Last modified:April 29, 2008 - v1
Checksum:iE0D092CA3BC44868
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ489736 Genomic DNA Translation: ACA81993.1
RefSeqiWP_004899587.1, NC_010471.1

Genome annotation databases

EnsemblBacteriaiACA81993; ACA81993; LCK_00160
GeneIDi35824743
KEGGilci:LCK_00160

Similar proteinsi

Entry informationi

Entry nameiSYE_LEUCK
AccessioniPrimary (citable) accession number: B1MWU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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