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B1MW96 (UPPP_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:LCK_01638
OrganismLeuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]
Taxonomic identifier349519 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197381

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane47 – 6721Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane259 – 27921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B1MW96 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 9E0CF53300F4176E

FASTA28231,287
        10         20         30         40         50         60 
MFDFIKSIII GIVEGLTEFL PVSSTGHIIL AEALMKIPGG MVWTKSFTAV FDYAIQLGAI 

        70         80         90        100        110        120 
FAVIQLYFHK LNPFSPRKTS REQFQTWRLW IKVIVGVLPA MVFGLLLNNF MDAHLLNPWV 

       130        140        150        160        170        180 
VSATLIIYGI AFIVIENRQK NIAPVVTEVN RITFKMALFI GLFQVLSLVP GTSRSGATIL 

       190        200        210        220        230        240 
GAVILGASRF VAAEFSFFLS IPVMFGVTIL KVGSFLLKGG SFTGAQLFVM LIGFVVSWVV 

       250        260        270        280 
ALFAIKVMMR YIQNNDFKIF GWYRIVVGIL FLILGIAGLV KM 

« Hide

References

[1]"Complete genome sequence of Leuconostoc citreum KM20."
Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K.
J. Bacteriol. 190:3093-3094(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KM20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ489736 Genomic DNA. Translation: ACA83461.1.
RefSeqYP_001728905.1. NC_010471.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349519.LCK_01638.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA83461; ACA83461; LCK_01638.
GeneID6063676.
KEGGlci:LCK_01638.
PATRIC32616656. VBILeuCit37309_1772.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMATEVNRIT.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycLCIT349519:GHNF-1690-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_LEUCK
AccessionPrimary (citable) accession number: B1MW96
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families