B1MW96 (UPPP_LEUCK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	LCK_01638

Organism

Leuconostoc citreum (strain KM20) [Complete proteome] [HAMAP]

Taxonomic identifier

349519 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Leuconostocaceae › Leuconostoc › Leuconostoc citreum

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000197381
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Transmembrane	259 – 279	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B1MW96 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 9E0CF53300F4176E	FASTA	282	31,287
	10 20 30 40 50 60 MFDFIKSIII GIVEGLTEFL PVSSTGHIIL AEALMKIPGG MVWTKSFTAV FDYAIQLGAI 70 80 90 100 110 120 FAVIQLYFHK LNPFSPRKTS REQFQTWRLW IKVIVGVLPA MVFGLLLNNF MDAHLLNPWV 130 140 150 160 170 180 VSATLIIYGI AFIVIENRQK NIAPVVTEVN RITFKMALFI GLFQVLSLVP GTSRSGATIL 190 200 210 220 230 240 GAVILGASRF VAAEFSFFLS IPVMFGVTIL KVGSFLLKGG SFTGAQLFVM LIGFVVSWVV 250 260 270 280 ALFAIKVMMR YIQNNDFKIF GWYRIVVGIL FLILGIAGLV KM

References

[1]

"Complete genome sequence of Leuconostoc citreum KM20." Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S., Lee S., Park H.-S., Park Y.-H., Oh T.K. J. Bacteriol. 190:3093-3094(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KM20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ489736 Genomic DNA. Translation: ACA83461.1.
RefSeq	YP_001728905.1. NC_010471.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	349519.LCK_01638.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACA83461; ACA83461; LCK_01638.
GeneID	6063676.
KEGG	lci:LCK_01638.
PATRIC	32616656. VBILeuCit37309_1772.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	NDWLDKH.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	LCIT349519:GHNF-1690-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_LEUCK

Accession

Primary (citable) accession number: B1MW96

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program