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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Leuconostoc citreum (strain KM20)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpm), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (pgm)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Binding sitei212ATPUniRule annotation1
Binding sitei301ATP; via carbonyl oxygenUniRule annotation1
Binding sitei332ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi361 – 364ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:LCK_01611
OrganismiLeuconostoc citreum (strain KM20)
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
Proteomesi
  • UP000002166 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000963561 – 405Phosphoglycerate kinaseAdd BLAST405

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349519.LCK_01611

Structurei

3D structure databases

ProteinModelPortaliB1MW69
SMRiB1MW69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B1MW69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLTVSDLE LSGKKVLMRV DFNVPIKAGV IGNDNRIVAA LPTIKYVLEN
60 70 80 90 100
NGRAILFSHL GRIKSEDDKK ELSLAPVAAR LGELLGKNVK FVPHTRGEEL
110 120 130 140 150
ESAINALQDG EVLMVENTRF EDVVDGVEVK NESKNNPELG KYWAGLGDDL
160 170 180 190 200
FINDAFGTAH RAHASNVGIA SNVSQVAAGF LMEKEIKFLG DAVANPVRPF
210 220 230 240 250
VAIIGGAKVS DKIEIVKSLL AKADKVIVGG GMAYTFDAAK GEKIGNSLFE
260 270 280 290 300
ADKVELAKEL MAEAGDKLVL PVDSIAADAF SNDAKTEVVD ATAGIPDGYM
310 320 330 340 350
GLDIGPKSVK LLQDTLADAK TVVWNGPMGV FEMPNFAKGT LAIGEELVKV
360 370 380 390 400
TENGGTTIVG GGDSTAAVQQ LGVADKLSHI STGGGASLEY LEGKELPGIA

SISEK
Length:405
Mass (Da):42,600
Last modified:April 29, 2008 - v1
Checksum:i785BF98F29B455B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ489736 Genomic DNA Translation: ACA83434.1
RefSeqiWP_012305438.1, NC_010471.1

Genome annotation databases

EnsemblBacteriaiACA83434; ACA83434; LCK_01611
GeneIDi35826509
KEGGilci:LCK_01611

Similar proteinsi

Entry informationi

Entry nameiPGK_LEUCK
AccessioniPrimary (citable) accession number: B1MW69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health