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Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl- (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Solute carrier family 4 member 3
Gene namesi
Name:SLC4A3
OrganismiPlecturocebus moloch (Dusky titi monkey) (Callicebus moloch)
Taxonomic identifieri9523 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniPitheciidaeCallicebinaePlecturocebus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 708CytoplasmicAdd BLAST708
Transmembranei709 – 731HelicalSequence analysisAdd BLAST23
Transmembranei737 – 774HelicalSequence analysisAdd BLAST38
Transmembranei794 – 816HelicalSequence analysisAdd BLAST23
Transmembranei826 – 847HelicalSequence analysisAdd BLAST22
Transmembranei893 – 910HelicalSequence analysisAdd BLAST18
Topological domaini911 – 925CytoplasmicSequence analysisAdd BLAST15
Transmembranei926 – 946HelicalSequence analysisAdd BLAST21
Transmembranei980 – 1002HelicalSequence analysisAdd BLAST23
Transmembranei1028 – 1049HelicalSequence analysisAdd BLAST22
Transmembranei1083 – 1128HelicalSequence analysisAdd BLAST46
Transmembranei1155 – 1191HelicalSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003855141 – 1232Anion exchange protein 3Add BLAST1232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei175PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei295Omega-N-methylarginineBy similarity1
Lipidationi1165S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiB1MTL0.

Structurei

3D structure databases

ProteinModelPortaliB1MTL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni709 – 1232Membrane (anion exchange)Add BLAST524

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 149Poly-GluAdd BLAST14
Compositional biasi152 – 161Pro-rich10
Compositional biasi308 – 313Poly-Lys6
Compositional biasi442 – 445Poly-Ser4
Compositional biasi1184 – 1187Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF15. PTHR11453:SF15. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MTL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TSGRHTRRKR KKEKTSVPPS EGTPPIQEEG GAGVDEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPPPSGS PPKAKFSIGS DEDDSPGLPG RAAVTKPLPS VGPRTDKSPQ
210 220 230 240 250
HSGSFPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA LGNPGGPEQQ
260 270 280 290 300
VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG
310 320 330 340 350
LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED
360 370 380 390 400
VEEETERWGK PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV
410 420 430 440 450
ETMIVSDQIR PEDRASVLRT LLLKHSHPND DKDSGFFPRN PSSSSMNSVL
460 470 480 490 500
GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP HDPDAKEKPL HMPGGDSHRG
510 520 530 540 550
KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV LLESVLEVPV
560 570 580 590 600
PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA
610 620 630 640 650
ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG
660 670 680 690 700
GYTAPGKELS LELGGSEATP EDDPLLRTGS IFGGLVRDVR RRYPYYPSDL
710 720 730 740 750
RDALHSQCVA AVLFIYFAAL SPAITFGGLL GEKTEGLMGV SELIVSTAVL
760 770 780 790 800
GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK FCRAQDLEYL TGRVWVGLWL
810 820 830 840 850
VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH
860 870 880 890 900
PLLPFYPPEG ALEGSLEAGL EPNGSALPPT EGPRGPRNQP NTALLSLILM
910 920 930 940 950
LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY
960 970 980 990 1000
TQKLTVPTGL SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI
1010 1020 1030 1040 1050
FMETQITALI VSQKARRLLK GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT
1060 1070 1080 1090 1100
VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE QRVTGVLIAS LVGLSIVMGA
1110 1120 1130 1140 1150
VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH HPEQPYVTKV
1160 1170 1180 1190 1200
KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF
1210 1220 1230
QDRELQALDS EDAEPNFDED GQDEYNELHM PV
Length:1,232
Mass (Da):135,882
Last modified:April 29, 2008 - v1
Checksum:i28A41DF3201753AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000640 Genomic DNA. Translation: ACA64872.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000640 Genomic DNA. Translation: ACA64872.1.

3D structure databases

ProteinModelPortaliB1MTL0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB1MTL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF15. PTHR11453:SF15. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3A3_PLEMO
AccessioniPrimary (citable) accession number: B1MTL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.