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B1MTL0 (B3A3_CALMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anion exchange protein 3

Short name=AE 3
Short name=Anion exchanger 3
Alternative name(s):
Solute carrier family 4 member 3
Gene names
Name:SLC4A3
OrganismCallicebus moloch (Dusky titi monkey)
Taxonomic identifier9523 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniPitheciidaeCallicebinaeCallicebus

Protein attributes

Sequence length1232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl- By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Keywords
   Biological processAnion exchange
Antiport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMLipoprotein
Palmitate
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioninorganic anion exchanger activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12321232Anion exchange protein 3
PRO_0000385514

Regions

Topological domain1 – 708708Cytoplasmic
Transmembrane709 – 73123Helical; Potential
Transmembrane737 – 77438Helical; Potential
Transmembrane794 – 81623Helical; Potential
Transmembrane826 – 84722Helical; Potential
Transmembrane893 – 91018Helical; Potential
Topological domain911 – 92515Cytoplasmic Potential
Transmembrane926 – 94621Helical; Potential
Transmembrane980 – 100223Helical; Potential
Transmembrane1028 – 104922Helical; Potential
Transmembrane1083 – 112846Helical; Potential
Transmembrane1155 – 119137Helical; Potential
Region709 – 1232524Membrane (anion exchange)
Compositional bias136 – 14914Poly-Glu
Compositional bias152 – 16110Pro-rich
Compositional bias308 – 3136Poly-Lys
Compositional bias442 – 4454Poly-Ser
Compositional bias1184 – 11874Poly-Leu

Amino acid modifications

Lipidation11651S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
B1MTL0 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 28A41DF3201753AC

FASTA1,232135,882
        10         20         30         40         50         60 
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE 

        70         80         90        100        110        120 
KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSGRHTRRKR KKEKTSVPPS 

       130        140        150        160        170        180 
EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPPSGS PPKAKFSIGS DEDDSPGLPG 

       190        200        210        220        230        240 
RAAVTKPLPS VGPRTDKSPQ HSGSFPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA 

       250        260        270        280        290        300 
LGNPGGPEQQ VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG 

       310        320        330        340        350        360 
LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED VEEETERWGK 

       370        380        390        400        410        420 
PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV ETMIVSDQIR PEDRASVLRT 

       430        440        450        460        470        480 
LLLKHSHPND DKDSGFFPRN PSSSSMNSVL GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP 

       490        500        510        520        530        540 
HDPDAKEKPL HMPGGDSHRG KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV 

       550        560        570        580        590        600 
LLESVLEVPV PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA 

       610        620        630        640        650        660 
ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG GYTAPGKELS 

       670        680        690        700        710        720 
LELGGSEATP EDDPLLRTGS IFGGLVRDVR RRYPYYPSDL RDALHSQCVA AVLFIYFAAL 

       730        740        750        760        770        780 
SPAITFGGLL GEKTEGLMGV SELIVSTAVL GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK 

       790        800        810        820        830        840 
FCRAQDLEYL TGRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF 

       850        860        870        880        890        900 
YKLYKVFTEH PLLPFYPPEG ALEGSLEAGL EPNGSALPPT EGPRGPRNQP NTALLSLILM 

       910        920        930        940        950        960 
LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY TQKLTVPTGL 

       970        980        990       1000       1010       1020 
SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI FMETQITALI VSQKARRLLK 

      1030       1040       1050       1060       1070       1080 
GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE 

      1090       1100       1110       1120       1130       1140 
QRVTGVLIAS LVGLSIVMGA VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH 

      1150       1160       1170       1180       1190       1200 
HPEQPYVTKV KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF 

      1210       1220       1230 
QDRELQALDS EDAEPNFDED GQDEYNELHM PV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DP000640 Genomic DNA. Translation: ACA64872.1.

3D structure databases

ProteinModelPortalB1MTL0.
SMRB1MTL0. Positions 692-733.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEB1MTL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.1100.10. 1 hit.
InterProIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMSSF55804. SSF55804. 2 hits.
TIGRFAMsTIGR00834. ae. 1 hit.
PROSITEPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3A3_CALMO
AccessionPrimary (citable) accession number: B1MTL0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families