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B1MTL0

- B3A3_CALMO

UniProt

B1MTL0 - B3A3_CALMO

Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Callicebus moloch (Dusky titi monkey)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl- By similarity.By similarity

    GO - Molecular functioni

    1. inorganic anion exchanger activity Source: InterPro

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 3
    Short name:
    AE 3
    Short name:
    Anion exchanger 3
    Alternative name(s):
    Solute carrier family 4 member 3
    Gene namesi
    Name:SLC4A3
    OrganismiCallicebus moloch (Dusky titi monkey)
    Taxonomic identifieri9523 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniPitheciidaeCallicebinaeCallicebus

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12321232Anion exchange protein 3PRO_0000385514Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi1165 – 11651S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiB1MTL0.

    Structurei

    3D structure databases

    ProteinModelPortaliB1MTL0.
    SMRiB1MTL0. Positions 692-733.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 708708CytoplasmicAdd
    BLAST
    Topological domaini911 – 92515CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei709 – 73123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei737 – 77438HelicalSequence AnalysisAdd
    BLAST
    Transmembranei794 – 81623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei826 – 84722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei893 – 91018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei926 – 94621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei980 – 100223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1028 – 104922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1083 – 112846HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1155 – 119137HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni709 – 1232524Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi136 – 14914Poly-GluAdd
    BLAST
    Compositional biasi152 – 16110Pro-rich
    Compositional biasi308 – 3136Poly-Lys
    Compositional biasi442 – 4454Poly-Ser
    Compositional biasi1184 – 11874Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 2 hits.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1MTL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL     50
    ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP 100
    TSGRHTRRKR KKEKTSVPPS EGTPPIQEEG GAGVDEEEEE EEEEEGESEA 150
    EPVEPPPSGS PPKAKFSIGS DEDDSPGLPG RAAVTKPLPS VGPRTDKSPQ 200
    HSGSFPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA LGNPGGPEQQ 250
    VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG 300
    LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED 350
    VEEETERWGK PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV 400
    ETMIVSDQIR PEDRASVLRT LLLKHSHPND DKDSGFFPRN PSSSSMNSVL 450
    GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP HDPDAKEKPL HMPGGDSHRG 500
    KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV LLESVLEVPV 550
    PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA 600
    ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG 650
    GYTAPGKELS LELGGSEATP EDDPLLRTGS IFGGLVRDVR RRYPYYPSDL 700
    RDALHSQCVA AVLFIYFAAL SPAITFGGLL GEKTEGLMGV SELIVSTAVL 750
    GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK FCRAQDLEYL TGRVWVGLWL 800
    VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH 850
    PLLPFYPPEG ALEGSLEAGL EPNGSALPPT EGPRGPRNQP NTALLSLILM 900
    LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY 950
    TQKLTVPTGL SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI 1000
    FMETQITALI VSQKARRLLK GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT 1050
    VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE QRVTGVLIAS LVGLSIVMGA 1100
    VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH HPEQPYVTKV 1150
    KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF 1200
    QDRELQALDS EDAEPNFDED GQDEYNELHM PV 1232
    Length:1,232
    Mass (Da):135,882
    Last modified:April 29, 2008 - v1
    Checksum:i28A41DF3201753AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000640 Genomic DNA. Translation: ACA64872.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000640 Genomic DNA. Translation: ACA64872.1 .

    3D structure databases

    ProteinModelPortali B1MTL0.
    SMRi B1MTL0. Positions 692-733.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B1MTL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002979. Anion_exchange_3.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF15. PTHR11453:SF15. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 2 hits.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01189. ANIONEXHNGR3.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiB3A3_CALMO
    AccessioniPrimary (citable) accession number: B1MTL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 13, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3