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B1MTL0

- B3A3_CALMO

UniProt

B1MTL0 - B3A3_CALMO

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Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Callicebus moloch (Dusky titi monkey)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl- By similarity.By similarity

GO - Molecular functioni

  1. inorganic anion exchanger activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Solute carrier family 4 member 3
Gene namesi
Name:SLC4A3
OrganismiCallicebus moloch (Dusky titi monkey)
Taxonomic identifieri9523 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniPitheciidaeCallicebinaeCallicebus

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12321232Anion exchange protein 3PRO_0000385514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi1165 – 11651S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiB1MTL0.

Structurei

3D structure databases

ProteinModelPortaliB1MTL0.
SMRiB1MTL0. Positions 692-733.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 708708CytoplasmicAdd
BLAST
Topological domaini911 – 92515CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei709 – 73123HelicalSequence AnalysisAdd
BLAST
Transmembranei737 – 77438HelicalSequence AnalysisAdd
BLAST
Transmembranei794 – 81623HelicalSequence AnalysisAdd
BLAST
Transmembranei826 – 84722HelicalSequence AnalysisAdd
BLAST
Transmembranei893 – 91018HelicalSequence AnalysisAdd
BLAST
Transmembranei926 – 94621HelicalSequence AnalysisAdd
BLAST
Transmembranei980 – 100223HelicalSequence AnalysisAdd
BLAST
Transmembranei1028 – 104922HelicalSequence AnalysisAdd
BLAST
Transmembranei1083 – 112846HelicalSequence AnalysisAdd
BLAST
Transmembranei1155 – 119137HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni709 – 1232524Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 14914Poly-GluAdd
BLAST
Compositional biasi152 – 16110Pro-rich
Compositional biasi308 – 3136Poly-Lys
Compositional biasi442 – 4454Poly-Ser
Compositional biasi1184 – 11874Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1MTL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TSGRHTRRKR KKEKTSVPPS EGTPPIQEEG GAGVDEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPPPSGS PPKAKFSIGS DEDDSPGLPG RAAVTKPLPS VGPRTDKSPQ
210 220 230 240 250
HSGSFPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA LGNPGGPEQQ
260 270 280 290 300
VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG
310 320 330 340 350
LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED
360 370 380 390 400
VEEETERWGK PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV
410 420 430 440 450
ETMIVSDQIR PEDRASVLRT LLLKHSHPND DKDSGFFPRN PSSSSMNSVL
460 470 480 490 500
GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP HDPDAKEKPL HMPGGDSHRG
510 520 530 540 550
KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV LLESVLEVPV
560 570 580 590 600
PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA
610 620 630 640 650
ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG
660 670 680 690 700
GYTAPGKELS LELGGSEATP EDDPLLRTGS IFGGLVRDVR RRYPYYPSDL
710 720 730 740 750
RDALHSQCVA AVLFIYFAAL SPAITFGGLL GEKTEGLMGV SELIVSTAVL
760 770 780 790 800
GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK FCRAQDLEYL TGRVWVGLWL
810 820 830 840 850
VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH
860 870 880 890 900
PLLPFYPPEG ALEGSLEAGL EPNGSALPPT EGPRGPRNQP NTALLSLILM
910 920 930 940 950
LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY
960 970 980 990 1000
TQKLTVPTGL SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI
1010 1020 1030 1040 1050
FMETQITALI VSQKARRLLK GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT
1060 1070 1080 1090 1100
VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE QRVTGVLIAS LVGLSIVMGA
1110 1120 1130 1140 1150
VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH HPEQPYVTKV
1160 1170 1180 1190 1200
KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF
1210 1220 1230
QDRELQALDS EDAEPNFDED GQDEYNELHM PV
Length:1,232
Mass (Da):135,882
Last modified:April 29, 2008 - v1
Checksum:i28A41DF3201753AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000640 Genomic DNA. Translation: ACA64872.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000640 Genomic DNA. Translation: ACA64872.1 .

3D structure databases

ProteinModelPortali B1MTL0.
SMRi B1MTL0. Positions 692-733.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B1MTL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002979. Anion_exchange_3.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF15. PTHR11453:SF15. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 2 hits.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01189. ANIONEXHNGR3.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiB3A3_CALMO
AccessioniPrimary (citable) accession number: B1MTL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: April 29, 2008
Last modified: October 1, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3