B1MP24 (B1MP24_MYCA9) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

MAB_1993

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1MP24 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: B9C508A3CEAE3BE6	FASTA	326	35,404
	10 20 30 40 50 60 MTTNPLDRDG PVAELQDPGS IADRLTAVQP GEIAFSVEFM PPRDEAAEAR LWRAARVFER 70 80 90 100 110 120 YRPVFVSVTY GAGGSTRDRT VRVTGELAEN TTLLPVAHLT AVGHTVDELR AMVGAYVDRG 130 140 150 160 170 180 ITNILALRGD PAGDVNAEWV PHPGGLTYAE QLVRLVRDLG DFHVGVASFP EGHPQAIDLE 190 200 210 220 230 240 SDTANLVNKL RAGAEYSITQ MFFDVDDYLR LRDRVVAADP EQGAKPIVPG LMPITSLRSV 250 260 270 280 290 300 RRQVELSSST LPTALEERLL RAAGDGPEEN RDEVRKVGVE VTTTMASRLL AEGVPCLHFM 310 320 TLNFARATSE VLENLGVRVT PGTARG

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM62075.1.
RefSeq	YP_001702729.1. NC_010397.1.
3D structure databases
ProteinModelPortal	B1MP24.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MP24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000005640; EBMYCP00000005579; EBMYCG00000005638.
GeneID	5964507.
GenomeReviews	Gene locus MAB_1993 in contig CU458896_GR.
KEGG	mab:MAB_1993.
PATRIC	17975693. VBIMycAbs55940_2028.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK758165.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1MP24_MYCA9

Accession

Primary (citable) accession number: B1MP24

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)