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B1MKQ3 (B1MKQ3_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:MAB_1257
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B1MKQ3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: F84A40E112826D2E

FASTA33736,475
        10         20         30         40         50         60 
MAAVDMGTPG MVSTAMRTVG PAISKRVLLA EPRGYCAGVD RAVETVERAL EKHGAPVYVR 

        70         80         90        100        110        120 
HEIVHNRYVV DTLAKAGAIF VDETDEVPEG AIVVFSAHGV APTVHEKAAE RNLKTIDATC 

       130        140        150        160        170        180 
PLVTKVHQEA KRFARDDFDI LLIGHEGHEE VIGTAGEAPD HVQLVDGPNA VDNVTVRDEN 

       190        200        210        220        230        240 
KVIWLSQTTL SVDETMETVQ RLRERFPTLQ DPPSDDICYA TQNRQVAVKA MAPECELVIV 

       250        260        270        280        290        300 
VGSRNSSNSV RLVEVALNAG SRASYLVDYA EDIDPAWLEG VTTVGVTSGA SVPEVLVRGV 

       310        320        330 
LERLAEHGYG EVQPVTTANE TLVFALPREL RASRRSG

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM61345.1.
RefSeqYP_001701999.1. NC_010397.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB1MKQ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000007253; EBMYCP00000007192; EBMYCG00000007251.
GeneID5963781.
GenomeReviewsGene locus MAB_1257 in contig CU458896_GR.
KEGGmab:MAB_1257.
PATRIC17974199. VBIMycAbs55940_1294.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016858.
HOGENOMHBG335228.
OMAAMAPECD.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1MKQ3_MYCA9
AccessionPrimary (citable) accession number: B1MKQ3
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info