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B1MKN0 (COAA_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pantothenate kinase
EC=2.7.1.33
Alternative name(s):
Pantothenic acid kinase
Gene names
Name:coaA
Ordered Locus Names:MAB_1234c
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215

Subcellular location

Cytoplasm By similarity HAMAP MF_00215.

Sequence similarities

Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantothenate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Pantothenate kinase HAMAP MF_00215
PRO_1000099937

Regions

Nucleotide binding95 – 1028ATP Potential

Sequences

Sequence LengthMass (Da)Tools
B1MKN0 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 05BFF1EB99E18C1B

FASTA31035,408
        10         20         30         40         50         60 
MPRLSEPSPY VEFDRKQWRA LRKSTPLVLT EEELIGLRGL GEQIDLTEVA EVYLPLARLI 

        70         80         90        100        110        120 
HLQVAARQRL FAATATFLGD QHPDRLVPFV IGVAGSVAVG KSTTARVLQA LLARWDHHPR 

       130        140        150        160        170        180 
VDLVTTDGFL YPNAELSRRN IMHRKGFPES YNRRGLLRFV TEVKSGAREV TAPVYSHLLY 

       190        200        210        220        230        240 
DIIKNEKHVV QQPDILILEG LNVLQTGPTL MVSDLFDFSI YVDARIEDIE QWYISRFLAM 

       250        260        270        280        290        300 
RSTSFANPSS HFHHYAKLSD KQATLAAQEI WHSINLPNLL ENILPTRPRA TLVLRKDADH 

       310 
SINRLRLRKL

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM61322.1.
RefSeqYP_001701976.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MKN0.
SMRB1MKN0. Positions 5-310.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MKN0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000004142; EBMYCP00000004081; EBMYCG00000004140.
GeneID5963758.
GenomeReviewsGene locus MAB_1234c in contig CU458896_GR.
KEGGmab:MAB_1234c.
PATRIC17974157. VBIMycAbs55940_1273.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016369.
HOGENOMHBG732538.
OMAEVYLPLS.
ProtClustDBPRK05439.

Enzyme and pathway databases

BioCycMABS561007:MAB_1234C-MONOMER.

Family and domain databases

HAMAPMF_00215. Pantothen_kinase_1.
[Tree]
InterProIPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
KOK00867.
PANTHERPTHR10285:SF7. PanK_bact. 1 hit.
PfamPF00485. PRK. 1 hit.
[Graphical view]
PIRSFPIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMsTIGR00554. PanK_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAA_MYCA9
AccessionPrimary (citable) accession number: B1MKN0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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