B1MJX0 (AHPD_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	MAB_4407c

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_0000359495
Sites
	Active site	130	1	Proton donor By similarity
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity
	Disulfide bond	133		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1MJX0 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: B5FABC9941FEB559	FASTA	175	18,705
	10 20 30 40 50 60 MSIENLKEAL PEYAKDLKLN LGTVARGTVL SQSQLWGTLV ATAAATRNEQ VFKEIREEAA 70 80 90 100 110 120 GILTPEALDA ALGAASIMAM TNVFYRGRGF LDGAYDDLRP GLRMNIIGNP GVDKSEFELW 130 140 150 160 170 SFAVSTINGC HYCVGSHEKV LREAGLTREQ VLEALKIAAI VAGVAQALAT VPALV

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM64477.1.
RefSeq	YP_001705131.1. NC_010397.1.
3D structure databases
ProteinModelPortal	B1MJX0.
SMR	B1MJX0. Positions 2-174.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MJX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000004395; EBMYCP00000004334; EBMYCG00000004393.
GeneID	5966866.
GenomeReviews	Gene locus MAB_4407c in contig CU458896_GR.
KEGG	mab:MAB_4407c.
PATRIC	17980636. VBIMycAbs55940_4482.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016698.
HOGENOM	HBG414634.
OMA	RAGLRMN.
ProtClustDB	CLSK791846.
Enzyme and pathway databases
BioCyc	MABS561007:MAB_4407C-MONOMER.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_MYCA9

Accession

Primary (citable) accession number: B1MJX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program