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B1MJT8

- ACDH2_MYCA9

UniProt

B1MJT8 - ACDH2_MYCA9

Protein

Acetaldehyde dehydrogenase 2

Gene

MAB_4374

Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261Acyl-thioester intermediateUniRule annotation
    Binding sitei284 – 2841NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 94NADUniRule annotation
    Nucleotide bindingi157 – 1659NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciMABS36809-WGS:GSQO-4392-MONOMER.
    MABS561007:GJTG-4392-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Ordered Locus Names:MAB_4374
    OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196)
    Taxonomic identifieri561007 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus
    ProteomesiUP000007137: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Acetaldehyde dehydrogenase 2PRO_0000387671Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561007.MAB_4374.

    Structurei

    3D structure databases

    ProteinModelPortaliB1MJT8.
    SMRiB1MJT8. Positions 1-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHARHEQL.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1MJT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIIGSGNIG TDLMIKVIRR SRILSMGAMV GIDPTSDGLA RAARLGVATT    50
    ADGVEGLIHM EQFAEVAIIF DATSAATHRE NAARLAPYDK RLIDLTPAAV 100
    GPYVVPPVNL GAHIASGATN LNMVTCGGQA TIPIVHAVSR VAPVVYAEIV 150
    ASISSRSAGP GTRANIDEFT ETTARAIEQV GGAARGKAII VLNPADPPPL 200
    MRDTVFCLVG DADHGTIRRS VKEMIAEVST YVPGYRLKQD VQFDRVDEPM 250
    RALLRDTTGT VTTKVSVFLE VEGAGHYLPS YAGNLDIMTS AALHTAESMV 300
    RGGDSSQEFG I 311
    Length:311
    Mass (Da):32,695
    Last modified:April 29, 2008 - v1
    Checksum:iE5F13F82F0CB6692
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU458896 Genomic DNA. Translation: CAM64445.1.
    RefSeqiYP_001705099.1. NC_010397.1.

    Genome annotation databases

    EnsemblBacteriaiCAM64445; CAM64445; MAB_4374.
    GeneIDi5966834.
    KEGGimab:MAB_4374.
    PATRICi17980576. VBIMycAbs55940_4452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU458896 Genomic DNA. Translation: CAM64445.1 .
    RefSeqi YP_001705099.1. NC_010397.1.

    3D structure databases

    ProteinModelPortali B1MJT8.
    SMRi B1MJT8. Positions 1-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561007.MAB_4374.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM64445 ; CAM64445 ; MAB_4374 .
    GeneIDi 5966834.
    KEGGi mab:MAB_4374.
    PATRICi 17980576. VBIMycAbs55940_4452.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HARHEQL.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci MABS36809-WGS:GSQO-4392-MONOMER.
    MABS561007:GJTG-4392-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
      Genoscope
      Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19977 / DSM 44196.

    Entry informationi

    Entry nameiACDH2_MYCA9
    AccessioniPrimary (citable) accession number: B1MJT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3