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B1MJT8

- ACDH2_MYCA9

UniProt

B1MJT8 - ACDH2_MYCA9

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Protein
Acetaldehyde dehydrogenase 2
Gene
MAB_4374
Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261Acyl-thioester intermediate By similarity
Binding sitei284 – 2841NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 94NAD By similarity
Nucleotide bindingi157 – 1659NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-4392-MONOMER.
MABS561007:GJTG-4392-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene namesi
Ordered Locus Names:MAB_4374
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus
ProteomesiUP000007137: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Acetaldehyde dehydrogenase 2UniRule annotation
PRO_0000387671Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561007.MAB_4374.

Structurei

3D structure databases

ProteinModelPortaliB1MJT8.
SMRiB1MJT8. Positions 1-301.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHARHEQL.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B1MJT8-1 [UniParc]FASTAAdd to Basket

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MAIIGSGNIG TDLMIKVIRR SRILSMGAMV GIDPTSDGLA RAARLGVATT    50
ADGVEGLIHM EQFAEVAIIF DATSAATHRE NAARLAPYDK RLIDLTPAAV 100
GPYVVPPVNL GAHIASGATN LNMVTCGGQA TIPIVHAVSR VAPVVYAEIV 150
ASISSRSAGP GTRANIDEFT ETTARAIEQV GGAARGKAII VLNPADPPPL 200
MRDTVFCLVG DADHGTIRRS VKEMIAEVST YVPGYRLKQD VQFDRVDEPM 250
RALLRDTTGT VTTKVSVFLE VEGAGHYLPS YAGNLDIMTS AALHTAESMV 300
RGGDSSQEFG I 311
Length:311
Mass (Da):32,695
Last modified:April 29, 2008 - v1
Checksum:iE5F13F82F0CB6692
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU458896 Genomic DNA. Translation: CAM64445.1.
RefSeqiYP_001705099.1. NC_010397.1.

Genome annotation databases

EnsemblBacteriaiCAM64445; CAM64445; MAB_4374.
GeneIDi5966834.
KEGGimab:MAB_4374.
PATRICi17980576. VBIMycAbs55940_4452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU458896 Genomic DNA. Translation: CAM64445.1 .
RefSeqi YP_001705099.1. NC_010397.1.

3D structure databases

ProteinModelPortali B1MJT8.
SMRi B1MJT8. Positions 1-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561007.MAB_4374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM64445 ; CAM64445 ; MAB_4374 .
GeneIDi 5966834.
KEGGi mab:MAB_4374.
PATRICi 17980576. VBIMycAbs55940_4452.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HARHEQL.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci MABS36809-WGS:GSQO-4392-MONOMER.
MABS561007:GJTG-4392-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
    Genoscope
    Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19977 / DSM 44196.

Entry informationi

Entry nameiACDH2_MYCA9
AccessioniPrimary (citable) accession number: B1MJT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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