B1MI02 (B1MI02_MYCA9) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370

Gene names

Ordered Locus Names:

MAB_0728

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733
Subcellular location	Cytoplasm By similarity SAAS SAAS004733.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS004733
Cellular component	Cytoplasm SAAS SAAS004733
Ligand	ATP-binding SAAS SAAS004733 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 SAAS SAAS004733 EMBL CAM60824.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1MI02 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 35960BBCB732451B	FASTA	362	38,038
	10 20 30 40 50 60 MPDMSERADK PSNSYAAAGV DIEAGDRAVE LFKKSVAKTH RPEVLGGIGG FAGLFALKGG 70 80 90 100 110 120 YREPVLAAST DGVGTKIAVA QAMDKRDTVG LDLVAMVVDD LVVCGAEPLF LQDYIAVGKV 130 140 150 160 170 180 VPERVSELVA GIAEGCAIAG CALLGGETAE HPGLMAPDDF DLSATGVGIV EADRVLGPDR 190 200 210 220 230 240 VRPGDVVIAM GSSGLHSNGY SLARHVLLEI DRMDLFGQVE EFGRTLGEEL LEPTRIYAKD 250 260 270 280 290 300 CLALAAETEV RTFCHVTGGG LAGNLARVIP DGLVAELDRG SWTPGPIFAM IAQRGRIERA 310 320 330 340 350 360 EMEKTFNMGV GMVAVVAPED VDRALAVLTA RHIDCWTLGT IKKSGKDSGS ESALLVGQHP RF

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM60824.1.
RefSeq	YP_001701478.1. NC_010397.1.
3D structure databases
ProteinModelPortal	B1MI02.
ModBase	Search...
Protein-protein interaction databases
STRING	B1MI02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000008184; EBMYCP00000008123; EBMYCG00000008182.
GeneID	5963262.
GenomeReviews	Gene locus MAB_0728 in contig CU458896_GR.
KEGG	mab:MAB_0728.
PATRIC	17973133. VBIMycAbs55940_0769.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016383.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1MI02_MYCA9

Accession

Primary (citable) accession number: B1MI02

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)