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B1MHY7 (B1MHY7_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:MAB_0713
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site161For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2571Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4031Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4591Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4621Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
B1MHY7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: E8CE46EA3F734A32

FASTA50453,758
        10         20         30         40         50         60 
MTAQPIELEN DPREECGVFG VWAPGEEVAK LTYYGLYALQ HRGQEAAGIA VADGSQIVVF 

        70         80         90        100        110        120 
KDLGLVSQVF DEQTLAAMRG HVAVGHCRYS TTGSVTWENA QPVFRTTAAG TGVALGHNGN 

       130        140        150        160        170        180 
LVNTAELTER ARDAGLINSK TPGMATTDSD IMGALLAHGA ADATLEQAAM TLLPTVRGAF 

       190        200        210        220        230        240 
CLVFADENTL YAARDPHGVR PLCLGRLDTG WVVASETAAL DIVGASFVRD IEPGELLAID 

       250        260        270        280        290        300 
ADGVRSSRFA NATPKTCVFE YVYLARPDSM LDGRSVHSTR VEIGRRLAAE HSVDADLVIG 

       310        320        330        340        350        360 
VPESGTPAAV GYAQGSGIPY GQGLMKNAYV GRTFIQPSQT IRQLGIRLKL NPLREVIRGK 

       370        380        390        400        410        420 
RLVVVDDSIV RGNTQRALVR MLREAGAAEV HVRIASPPVR WPCFYGIDFA SPAELIANAV 

       430        440        450        460        470        480 
ESDDEMLDAV RTAIGADSLG YISAEGMVAA TQEPRSRLCC ACFDGNYPIE LPKETALGKN 

       490        500 
VVEHMLAATA RETSSESSES VQAR

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM60809.1.
RefSeqYP_001701463.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MHY7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MHY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000005039; EBMYCP00000004978; EBMYCG00000005037.
GeneID5963247.
GenomeReviewsGene locus MAB_0713 in contig CU458896_GR.
KEGGmab:MAB_0713.
PATRIC17973099. VBIMycAbs55940_0752.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016850.
HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBPRK07847.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1MHY7_MYCA9
AccessionPrimary (citable) accession number: B1MHY7
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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