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B1MH53 (PSD_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MAB_0639c
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Phosphatidylserine decarboxylase beta chain By similarity
PRO_1000131470
Chain206 – 23732Phosphatidylserine decarboxylase alpha chain By similarity
PRO_1000131471

Sites

Site205 – 2062Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2061Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
B1MH53 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 0E2245C45E321380

FASTA23725,021
        10         20         30         40         50         60 
MARRPRPAGS EPDSGIPHIV ELVRSTIPPI HPAGLPFIAG GLGLAGLGVR NRWVRGTGLA 

        70         80         90        100        110        120 
LAGACAGFFR HPPRVPPNRA DVVVAAADGQ VCLVDRAVPP PELGLPAEPL PRISIFLSVF 

       130        140        150        160        170        180 
DVHVQRVPVA GEATAVIHRS GQFLSADRAE ASVANERNSV QIRTRTGHDV IVVQIAGLIA 

       190        200        210        220        230 
RRIVCHAKVG DQLSIGDTYG LIRFGSRVDT YLPEGSKILV QQGQRAVGAE TVLAELP

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM60737.1.
RefSeqYP_001701391.1. NC_010397.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB1MH53.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000005774; EBMYCP00000005713; EBMYCG00000005772.
GeneID5963175.
GenomeReviewsGene locus MAB_0639c in contig CU458896_GR.
KEGGmab:MAB_0639c.
PATRIC17972949. VBIMycAbs55940_0678.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycMABS561007:MAB_0639C-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCA9
AccessionPrimary (citable) accession number: B1MH53
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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