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B1MGV7 (B1MGV7_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate 1-decarboxylase HAMAP MF_00446
EC=4.1.1.11 HAMAP MF_00446
Alternative name(s):
Aspartate alpha-decarboxylase HAMAP MF_00446
Gene names
Name:panD HAMAP MF_00446
Ordered Locus Names:MAB_0542
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine By similarity. HAMAP MF_00446 SAAS SAAS003190

Catalytic activity

L-aspartate = beta-alanine + CO2. HAMAP MF_00446 SAAS SAAS003190

Cofactor

Pyruvoyl group By similarity. PIRSR PIRSR006246-1 HAMAP MF_00446 SAAS SAAS003190

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1. HAMAP MF_00446 SAAS SAAS003190

Subunit structure

Heterooctamer of four alpha and four beta subunits By similarity. HAMAP MF_00446 SAAS SAAS003190

Subcellular location

Cytoplasm By similarity HAMAP MF_00446 SAAS SAAS003190.

Post-translational modification

Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus By similarity. PIRSR PIRSR006246-3 HAMAP MF_00446

Sequence similarities

Belongs to the PanD family. HAMAP MF_00446

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region74 – 763Substrate binding By similarity HAMAP MF_00446 PIRSR PIRSR006246-2

Sites

Active site261Schiff-base intermediate with substrate; via pyruvic acid By similarity PIRSR PIRSR006246-1 HAMAP MF_00446
Active site591Proton donor By similarity PIRSR PIRSR006246-1 HAMAP MF_00446
Binding site581Substrate By similarity HAMAP MF_00446 PIRSR PIRSR006246-2

Amino acid modifications

Modified residue261Pyruvic acid (Ser) By similarity PIRSR PIRSR006246-3 HAMAP MF_00446

Sequences

Sequence LengthMass (Da)Tools
B1MGV7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 5FD8F4C0550D2321

FASTA14115,234
        10         20         30         40         50         60 
MMFRTMMKSK IHRATVTHAD LHYVGSVTID PDLMEAADLL EGEQVTIVDI DNGARLETYA 

        70         80         90        100        110        120 
ITGTRGSGVI GINGAAAHLV HPGDLVIIIA YGVMTDEEAR AFTPRVVFVD SDNKQVELGE 

       130        140 
HSDDPAYVPE NFGLVSPRGL V

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU458896 Genomic DNA. Translation: CAM60641.1.
RefSeqYP_001701295.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MGV7.
SMRB1MGV7. Positions 2-114.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1MGV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000008779; EBMYCP00000008718; EBMYCG00000008777.
GeneID5963079.
GenomeReviewsGene locus MAB_0542 in contig CU458896_GR.
KEGGmab:MAB_0542.
PATRIC17972757. VBIMycAbs55940_0582.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017253.
HOGENOMHBG302821.
OMALYSKIHR.

Family and domain databases

HAMAPMF_00446. PanD.
[Tree]
InterProIPR009010. Asp_de-COase-like_fold.
IPR003190. Asp_decarbox.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
KOK01579.
PANTHERPTHR21012. Asp_decarbox. 1 hit.
PfamPF02261. Asp_decarbox. 1 hit.
[Graphical view]
PIRSFPIRSF006246. Asp_decarbox. 1 hit.
ProDomPD009294. Asp_decarbox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50692. Asp_decarb_fold. 1 hit.
TIGRFAMsTIGR00223. PanD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1MGV7_MYCA9
AccessionPrimary (citable) accession number: B1MGV7
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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