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Protein

Glutamate decarboxylase

Gene

MAB_3740c

Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-3756-MONOMER.
MABS561007:GJTG-3756-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:MAB_3740cImported
OrganismiMycobacterium abscessus (strain ATCC 19977 / DSM 44196)Imported
Taxonomic identifieri561007 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium abscessus
ProteomesiUP000007137 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi561007.MAB_3740c.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
OMAiRNADRYP.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

B1MG69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSRDQFRL SAHAGKINAS AFSPAYTGRL STAPVPALRL PDEPMDPQAA
60 70 80 90 100
YRFIHDELML DGSSRLNLAT FVTTWMDPEA EKLMAETFDK NMIDKDEYPA
110 120 130 140 150
TAAIESRCVA MVADLFHADN LSTEDPSSAV GVSTIGSSEA VMLAGLALKW
160 170 180 190 200
RWRTKIGGTD GTGWKGRTPN LVMGSNVQVV WEKFCRYFDV EPRYLPMAKG
210 220 230 240 250
RYVITPEQVL EVVDEDTIGV VGILGTTFTG ELEPIAAICA ALDKLAATPG
260 270 280 290 300
KPDVPVHVDA ASGGFVVPFL HPELHWDFRL PRVVSINVSG HKYGLTYPGI
310 320 330 340 350
GFVVWRGKEH LPEDLVFRVN YLGGDMPTFT LNFSRPGNQV VGQYYNFLRL
360 370 380 390 400
GRAGYAQVMR CLSETARWFG DELGKSEHFE VITDGSAIPV VSFRLKGKRP
410 420 430 440 450
YTEFDISHSL RAFGWQVPAY TMPDDVTDIA VLRVVVREGF SGDLARALRD
460 470
DLNTVLKGLD ELKPNGHFDE VQPFAH
Length:476
Mass (Da):52,637
Last modified:April 29, 2008 - v1
Checksum:iB47A2333D52408D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU458896 Genomic DNA. Translation: CAM63814.1.

Genome annotation databases

EnsemblBacteriaiCAM63814; CAM63814; MAB_3740c.
PATRICi17979280. VBIMycAbs55940_3809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU458896 Genomic DNA. Translation: CAM63814.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi561007.MAB_3740c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM63814; CAM63814; MAB_3740c.
PATRICi17979280. VBIMycAbs55940_3809.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
OMAiRNADRYP.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciMABS36809-WGS:GSQO-3756-MONOMER.
MABS561007:GJTG-3756-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
    Genoscope
    Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19977 / DSM 44196Imported.

Entry informationi

Entry nameiB1MG69_MYCA9
AccessioniPrimary (citable) accession number: B1MG69
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.