B1MG32 (B1MG32_MYCA9) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	MAB_3703c

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	1078 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1MG32 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 7217E523ABA50C2B	FASTA	1,078	117,264
	10 20 30 40 50 60 MLDGRLNPHA PPGDGGDGPA WSRKRQPYEP PPRERGRSVV PYAELHAHSA FSFLDGASLP 70 80 90 100 110 120 EEMVQEAARL DLKALAITDH DGFYGVVRFA EAAKELGLPT VFGAELSLGG QGNTEDSVHL 130 140 150 160 170 180 LVLARGQEGY RRLSRQMAGA HLSGGTPKDR KGKPRYDLDA LTEAAGGHWH ILTGCRKGHV 190 200 210 220 230 240 RRALAGGGPV AAERALANLV DRFGADRVSI ELNRHGHPGE DERNAELAAL ARGFGVGVIA 250 260 270 280 290 300 TTAAHFATPE SGRLAMAMAA VRARKSLDDA AGWLDPVGGA HLRSGDEMAR LFSHYPEVVT 310 320 330 340 350 360 AAAELGEECA FDLRLIAPQL PPFDVPSGHT EDSWLRHLAL EGAARRYGPR AGAQKAYAQI 370 380 390 400 410 420 ERELEIIAQL NFPGYFLVVH DITQFCRRSD ILCQGRGSAA NSAVCYALGV TNVDPVDNGL 430 440 450 460 470 480 LFERFLSPAR DGPPDIDIDI ESDEREQAIQ YVYNKYGREY AAQVANVITY RGRMAVRDMA 490 500 510 520 530 540 KALGFAQGQQ DAWSKQMGHW GGLADAAAVD GIPPQVIQLA RQIKDFPRHM GIHSGGMVIC 550 560 570 580 590 600 DRPLADVVPV EWARMENRSV LQWDKDDCAA VGLVKFDLLG LGMLSALHYC IDLVREHKGI 610 620 630 640 650 660 DVDLAHINLK EQAVYEMLAR ADSVGVFQVE SRAQMATLPR LKPKCFYDLV VEVALIRPGP 670 680 690 700 710 720 IQGGSVHPYI RRYNKIDKDW QHDHPSMAAA LDKTLGVPLF QEQLMQLAVD VAGFSPAESD 730 740 750 760 770 780 QLRRAMGSKR SPERMERLRN RFYEGMRNLH GITGELADRI YEKLYAFANF GFPESHAQSF 790 800 810 820 830 840 ASLVFYSSWF KLHHPAAFCA ALLRAQPMGF YSPQSLVADA RRHGVTVHGP DVNASLSYAT 850 860 870 880 890 900 LENAGLEVRI GLGAVRHIGD DLAQAIVEER KVRGPFVSLL DLTGRIQLTT AQVEALATGG 910 920 930 940 950 960 ALGCFDMSRR EALWVAGAAA AQRPDRLPGV GVSSRIPALP EMGEVTRAAA DVWATGVSPD 970 980 990 1000 1010 1020 SYPTQFLRAR LDAMGVVPAK GLFGVPDGSR VLVAGAVTHR QRPATAAGVT FINLEDETGM 1030 1040 1050 1060 1070 VNVVCSVGLW ARYRKLAVTA RALIIRGQVQ NASGAVSVVA DQLRPLDLQI RSTSRDFR

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM63777.1.
RefSeq	YP_001704431.1. NC_010397.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B1MG32.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000007438; EBMYCP00000007377; EBMYCG00000007436.
GeneID	5966201.
GenomeReviews	Gene locus MAB_3703c in contig CU458896_GR.
KEGG	mab:MAB_3703c.
PATRIC	17979204. VBIMycAbs55940_3771.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B1MG32_MYCA9

Accession

Primary (citable) accession number: B1MG32

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)