B1MFZ9 (ADD_MYCA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosine deaminase
EC=3.5.4.4

Alternative name(s):
Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	MAB_3670c

Organism

Mycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]

Taxonomic identifier

561007 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Adenosine deaminase HAMAP MF_00540		PRO_1000128851
Sites
	Active site	208	1	Potential
	Active site	267	1	Potential
	Active site	300	1	Potential
	Active site	301	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	B1MFZ9-1 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 03473A10F7CC0BF6	FASTA	362	39,375
	10 20 30 40 50 60 MTAELDLVSI TQAPKALLHD HLDGGLRPGT VLDLARETGY ENLPAQDETA LASWFRTAAD 70 80 90 100 110 120 SGSLEQYLET FAHTVGVMQT ASALHRVAAE CVEDLAADGV VYAEVRFAPE LHIDAGLTLD 130 140 150 160 170 180 DVMDAVLAGF ADGERQASAA GKRIKVRTLV TAMRHAARSR EIAELAVKFR DRGAVGFDIA 190 200 210 220 230 240 GAEAGYPPTR HLDAFEYMRN ANSRFTIHAG EGFGLPSIHE AIAFCGADRL GHGVRIVDDI 250 260 270 280 290 300 DIGPDGTAHL GRLSSLLRDK RVPLELCPSS NVQTGAVESL ADHPFDLLAR LRFRVTVNTD 310 320 330 340 350 360 NRLMSDTTMS REMLRLVETF GYGWSDLQRF TINAMKSAFI PFDERLAIID DVIKPGYAVL IG

References

[1]

"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus." Genoscope Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU458896 Genomic DNA. Translation: CAM63744.1.
RefSeq	YP_001704398.1.
3D structure databases
ProteinModelPortal	B1MFZ9.
SMR	B1MFZ9. Positions 12-354.
ModBase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000005781; EBMYCP00000005720; EBMYCG00000005779.
GeneID	5966168.
GenomeReviews	Gene locus MAB_3670c in contig CU458896_GR.
KEGG	mab:MAB_3670c.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	PYYMAMN.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	MABS561007:MAB_3670C-MONOMER.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_MYCA9

Accession

Primary (citable) accession number: B1MFZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	August 10, 2010
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)