UniProtKB - B1MDQ5 (SYE_MYCA9)
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Protein
Glutamate--tRNA ligase
Gene
gltX
Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Status
Functioni
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation
Catalytic activityi
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 259 | ATPUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glutamate-tRNA ligase activity Source: UniProtKB-EC
- tRNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- glutamyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)Alternative name(s): Glutamyl-tRNA synthetaseUniRule annotation Short name: GluRSUniRule annotation |
Gene namesi | Name:gltXUniRule annotation Ordered Locus Names:MAB_3298c |
Organismi | Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) |
Taxonomic identifieri | 561007 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium abscessus |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000090091 | 1 – 496 | Glutamate--tRNA ligaseAdd BLAST | 496 |
Interactioni
Subunit structurei
Monomer.UniRule annotation
Protein-protein interaction databases
STRINGi | 561007.MAB_3298c. |
Structurei
3D structure databases
ProteinModelPortali | B1MDQ5. |
SMRi | B1MDQ5. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 12 – 22 | "HIGH" regionUniRule annotationAdd BLAST | 11 | |
Motifi | 256 – 260 | "KMSKS" regionUniRule annotation | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C20. Bacteria. COG0008. LUCA. |
HOGENOMi | HOG000252720. |
OMAi | AYYAFDT. |
Family and domain databases
CDDi | cd00808. GluRS_core. 1 hit. |
Gene3Di | 1.10.10.350. 1 hit. 1.10.1160.10. 1 hit. 1.10.8.70. 1 hit. 3.40.50.620. 2 hits. |
HAMAPi | MF_00022. Glu_tRNA_synth_type1. 1 hit. |
InterProi | View protein in InterPro IPR008925. aa-tRNA-synth_I_codon-bd. IPR020752. aa-tRNA-synth_I_codon-bd_sub1. IPR020751. aa-tRNA-synth_I_codon-bd_sub2. IPR004527. Glu-tRNA-ligase_bac/mito. IPR000924. Glu/Gln-tRNA-synth. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR020061. Glu_tRNA_lig_a-bdl. IPR033910. GluRS_core. IPR014729. Rossmann-like_a/b/a_fold. |
Pfami | View protein in Pfam PF00749. tRNA-synt_1c. 1 hit. |
PRINTSi | PR00987. TRNASYNTHGLU. |
SUPFAMi | SSF48163. SSF48163. 1 hit. |
TIGRFAMsi | TIGR00464. gltX_bact. 1 hit. |
i Sequence
Sequence statusi: Complete.
B1MDQ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNTKIRVRF CPSPTGTPHV GLIRTALFNW AYARHCGGDF VFRIEDTDAG
60 70 80 90 100
RDSEESYLAI LDALRWLGLD WDEGPEVGGP YEPYRQSQRK ELHREVVRKL
110 120 130 140 150
LEAGEAYEAF STAEEVEARH LAAGRNPKLG YDNYDRDLTE EQRAAFRAEG
160 170 180 190 200
RDPVVRLRMP DHDITWNDLV RGETTFAAGV VPDFALTRGN GDPLYTLVNP
210 220 230 240 250
VDDALMKITH VLRGEDLLPS TPRQIALYEA MIRIGVTDSI PAFAHLPSVL
260 270 280 290 300
GEGTKKLSKR DPQSNLFLHR DRGFIPEGLL NYLALLGWSI ADDHDIFSLA
310 320 330 340 350
EMVTAFDVTD VNSNPARFDQ KKADAINAEH IRLLAPEEFV TRLRTYFAAH
360 370 380 390 400
GHELGLDESA FAVAADLVQT RIVVLGDAWG LLKFLNDDAY AIDPGAARKE
410 420 430 440 450
LGEASLPVLD AAIGALESLE AWTTPAIEGA LKSALIEGLE LKPRKAFGPL
460 470 480 490
RVAVTGATVS PPLFESMELL GSGRTLTRLR NARSWENGVG DQTDSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU458896 Genomic DNA. Translation: CAM63374.1. |
Genome annotation databases
EnsemblBacteriai | CAM63374; CAM63374; MAB_3298c. |
Similar proteinsi
Entry informationi
Entry namei | SYE_MYCA9 | |
Accessioni | B1MDQ5Primary (citable) accession number: B1MDQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | April 29, 2008 | |
Last modified: | February 28, 2018 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |