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B1MDP3 (B1MDP3_MYCA9) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:MAB_3286c EMBL CAM63362.1
OrganismMycobacterium abscessus (strain ATCC 19977 / DSM 44196) [Complete proteome] [HAMAP]
Taxonomic identifier561007 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium abscessus

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain161 – 371211ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding189 – 24456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3261Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3381Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3381Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3401Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
B1MDP3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 2B492FC3D4594E90

FASTA38140,549
        10         20         30         40         50         60 
MNDSVGRSRA DQQRIKVALV FGGRSSEHAI SCVSAGSILR NLDQAVYEVV AVGVTPEGGW 

        70         80         90        100        110        120 
VLTDGDPAQL AISDRTLPQV TDASGTELLL ATDPRRAGQL VNVDSSAAGQ VLASVDVVFP 

       130        140        150        160        170        180 
VLHGPYGEDG TIQGLLELAG VPYVGAGVLA SAAGMDKEFT KKLLAAEGLP IGKYAVIRPR 

       190        200        210        220        230        240 
DTTLTLDQRE DLGLPVFVKP ARAGSSFGVS RVTAWEELPA AIAHARQYDP KVIVEAAIVG 

       250        260        270        280        290        300 
RELECGVLEF PDGDTRASVL GEIRVEGVNR DQTAAGAFYD FETKYLDDTA ELDVPAKVDD 

       310        320        330        340        350        360 
DVSDQIRELA VAAFRAIDCQ GLARVDFFLA EDGPLINEIN TMPGFTTISM YPRMWDATGV 

       370        380 
DYPTLLDAMV RTALARGTGL R 

« Hide

References

[1]"Acquisition of foreign virulence genes by the cystic fibrosis pathogen Mycobacterium abscessus."
Genoscope
Ripoll F., Pasek S., Schenowitz C., Dossat C., Barbe V., Rottman M., Heym B., Herrmann J.L., Daffe M., Brosch R., Risler J.L., Gaillard J.L.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19977 / DSM 44196.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU458896 Genomic DNA. Translation: CAM63362.1.
RefSeqYP_001704016.1. NC_010397.1.

3D structure databases

ProteinModelPortalB1MDP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING561007.MAB_3286c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM63362; CAM63362; MAB_3286c.
GeneID5965786.
KEGGmab:MAB_3286c.
PATRIC17978342. VBIMycAbs55940_3344.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycMABS36809-WGS:GSQO-3300-MONOMER.
MABS561007:GJTG-3300-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1MDP3_MYCA9
AccessionPrimary (citable) accession number: B1MDP3
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)